Novel Technologies for Target Delivery of Therapeutics to the Placenta during Pregnancy: A Review.
Novel Technologies for Target Delivery of Therapeutics to the Placenta during Pregnancy: A Review.
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DOI：
10.3390/genes12081255
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发表时间：
2021-08-17
期刊：
影响因子：
3.5
通讯作者：
Albrecht ED
中科院分区：
文献类型：
--
作者：
Pepe GJ;Albrecht ED
子宫螺旋动脉重构对胎盘血流灌注和胎儿生长发育至关重要，当受损时，会导致胎盘缺血和妊娠并发症，如胎儿生长受限、先兆子痫、早产。尽管不良妊娠的发生率很高，但目前的治疗选择有限。因此，研究转向了基因治疗技术的开发，这种技术可以在限制母亲和胎儿暴露的同时，向胎盘提供有针对性的“有效载荷”。本文综述了胎盘靶向多肽结合脂质体、修饰有特定多肽序列和胎盘基因启动子的纳米粒或腺病毒载体、通过母体静脉注射直接进入胎盘或子宫动脉，以及通过超声造影无创定位靶向与微泡结合的调控基因。该综述还对这些技术在各种动物模型中的有效性以及它们在受胎盘功能障碍影响的不良人类妊娠中靶向胎盘输送治疗药物和基因的可行性和潜在用途提供了一个视角。
Uterine spiral artery remodeling is essential for placental perfusion and fetal growth and, when impaired, results in placental ischemia and pregnancy complications, e.g., fetal growth restriction, preeclampsia, premature birth. Despite the high incidence of adverse pregnancies, current treatment options are limited. Accordingly, research has shifted to the development of gene therapy technologies that provide targeted delivery of “payloads” to the placenta while limiting maternal and fetal exposure. This review describes the current strategies, including placental targeting peptide-bound liposomes, nanoparticle or adenovirus constructs decorated with specific peptide sequences and placental gene promoters delivered via maternal IV injection, directly into the placenta or the uterine artery, as well as noninvasive site-selective targeting of regulating genes conjugated with microbubbles via contrast-enhanced ultrasound. The review also provides a perspective on the effectiveness of these technologies in various animal models and their practicability and potential use for targeted placental delivery of therapeutics and genes in adverse human pregnancies affected by placental dysfunction.
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DOI：
10.1042/cs20110627
发表时间：
2012-07
期刊：
Clinical science (London, England : 1979)
影响因子：
--
作者：
Davis EF;Newton L;Lewandowski AJ;Lazdam M;Kelly BA;Kyriakou T;Leeson P
通讯作者：
Leeson P
影响因子：
24
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通讯作者：
Lindner, Jonathan R.
影响因子：
3.6
作者：
Breyer, Benjamin;Jiang, Wei;He, Tong-Chuan
通讯作者：
He, Tong-Chuan
影响因子：
7.1
作者：
Breetveld, N. M.;Ghossein-Doha, C.;Spaanderman, M. E. A.
通讯作者：
Spaanderman, M. E. A.
DOI：
10.1152/ajpheart.00613.2020
发表时间：
2021-04-01
影响因子：
4.8
作者：
Albrecht, Eugene D.;Babischkin, Jeffery S.;Pepe, Gerald J.
通讯作者：
Pepe, Gerald J.