Concurrent administration of COVID-19 and influenza vaccines enhances Spike-specific antibody responses.
Concurrent administration of COVID-19 and influenza vaccines enhances Spike-specific antibody responses.
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同时接种 COVID-19 和流感疫苗可增强 Spike 特异性抗体反应。
DOI：
10.1101/2023.09.12.557347
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发表时间：
2023
期刊：
影响因子：
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通讯作者：
McNamara,RyanP
中科院分区：
文献类型：
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作者：
Barouch,SusannaE;Chicz,TarasM;Blanc,Ross;Barbati,DomenicR;Parker,LilyJ;Tong,Xin;McNamara,RyanP
背景二价 COVID-19 mRNA 加强剂于 2022 年秋季上市，并被推荐与季节性流感疫苗一起使用。然而，同时和单独接种这些疫苗的免疫原性仍不清楚。 方法在这里，我们通过系统血清学分析了在同一天或不同天接受二价 COVID-19 加强疫苗和流感疫苗的医护人员的抗体反应。在峰值反应时和疫苗接种后 6 个月后对抗体结合和功能反应进行了表征。结果与单独接种 COVID-19 和流感疫苗相比，在同时给药后的峰值和 6 个月后，对 SARS-CoV-2 XBB.1.5 的 IgG1 和中和反应更高。虽然在流感反应中没有观察到类似的结果，但同时接种并没有发现干扰。结论这些数据表明，同时接种这些疫苗可能会产生更高、更持久的 SARS-CoV-2 中和抗体反应，同时保持对流感的反应。
BackgroundThe bivalent COVID-19 mRNA boosters became available in fall 2022 and were recommended alongside the seasonal influenza vaccine. However, the immunogenicity of concurrent vs separate administration of these vaccines remains unclear.MethodsHere, we analyzed antibody responses in health care workers who received the bivalent COVID-19 booster and the influenza vaccine on the same day or on different days through systems serology. Antibody-binding and functional responses were characterized at peak responses and after 6 months following vaccination.ResultsIgG1 and neutralization responses to SARS-CoV-2 XBB.1.5 were higher at peak and after 6 months following concurrent administration as compared with separate administration of the COVID-19 and influenza vaccines. While similar results were not observed for influenza responses, no interference was noted with concurrent administration.ConclusionsThese data suggest that concurrent administration of these vaccines may yield higher and more durable SARS-CoV-2 neutralizing antibody responses while maintaining responses against influenza.