Mycoplasmas and ureaplasmas in patients with hypogammaglobulinaemia and their role in arthritis: microbiological observations over twenty years.
Mycoplasmas and ureaplasmas in patients with hypogammaglobulinaemia and their role in arthritis: microbiological observations over twenty years.
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低丙种球蛋白血症患者的支原体和解脲支原体及其在关节炎中的作用：二十年来的微生物学观察。
DOI：
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发表时间：
1994
影响因子：
27.4
通讯作者：
A. Webster
中科院分区：
文献类型：
--
作者：
P. Furr;D. Taylor;A. Webster
目的——研究低丙种球蛋白血症患者支原体和解脲支原体的发生情况以及这些微生物与化脓性关节炎的关系。方法——在大约 20 年的时间里，对 53 名男性和 38 名患有低丙种球蛋白血症的女性（其中大多数年龄不到 50 岁）进行了临床和微生物学检查。通过标准培养方法在咽喉、泌尿生殖道和关节中寻找支原体和解脲支原体，尽管在所有患者的三个部位中的情况不一致。结果——精氨酸水解支原体和解脲脲原体在低丙种球蛋白血症患者的痰/喉咙中出现的频率相似，但在免疫功能正常的患者中出现的频率并不比预期的高。然而，解脲支原体在男性和女性的泌尿生殖道中占主导地位，75% 的阴道标本中都发现了解脲支原体。与性别和年龄匹配的非性病患者、医院患者或健康受试者的尿液样本相比，低丙种球蛋白血症患者的尿液样本中精氨酸水解支原体的出现频率高出两到六倍，解脲支原体的出现频率高出两到三倍；这些差异具有统计学意义（p < 0.05）。增强的粘膜定植可能会增加扩散到远处部位（例如关节）的机会。在 91 名患者中，21 名 (23%) 患有累及一个或多个关节的化脓性关节炎。从其中 8 名患者（38%）的关节中分离出支原体和/或脲原体，但未分离出细菌。然而，尽管支原体或解脲支原体在粘膜部位定殖，有机会传播到关节，但在某些情况下显然没有发生。有时抗生素治疗在临床上失败，并概述了微生物学和管理建议。结论——与免疫功能正常的个体相比，低丙种球蛋白血症患者似乎更容易受到支原体和解脲支原体在粘膜（尤其是泌尿生殖道）定植的影响。这些微生物导致了这些患者中约五分之二的化脓性关节炎。
OBJECTIVES--To study the occurrence of mycoplasmas and ureaplasmas in patients with hypogammaglobulinaemia and the relationship of these micro-organisms to septic arthritis. METHODS--Over a period of about 20 years, 53 men and 38 women with hypogammaglobulinaemia, most of whom were less than 50 years old, were examined clinically and microbiologically. Mycoplasmas and ureaplasmas were sought in the throat, urogenital tract and joints by standard cultural methods, although not consistently in the three sites of all patients. RESULTS--Arginine-hydrolysing mycoplasmas and ureaplasmas occurred with similar frequency in the sputum/throat of the hypogammaglobulinaemic patients, but no more often than might be expected in immunocompetent patients. Ureaplasmas, however, dominated in the urogenital tracts of both men and women, being found in 75% of vaginal specimens. Arginine-hydrolysing mycoplasmas occurred two to six times more frequently and ureaplasmas two to three times more frequently in urine specimens from hypogammaglobulinaemic patients than they did in such specimens from sex- and age-matched non-venereal disease, hospital patients or healthy subjects; these differences were statistically significant (p < 0.05). Enhanced mucosal colonisation probably increases the chance of spread to distant sites, such as the joints. Of the 91 patients, 21 (23%) had septic arthritis involving one or more joints. Mycoplasmas and/or ureaplasmas, but not bacteria, were isolated from the joints of eight (38%) of these patients. However, dissemination to joints apparently had not occurred in some despite the opportunity by virtue of mycoplasmal or ureaplasmal colonisation at a mucosal site. Sometimes antibiotic therapy failed clinically, and microbiologically and recommendations for management are outlined. CONCLUSIONS--Hypogammaglobulinaemic patients appear to be more susceptible to colonisation of mucous membranes, especially of the urogenital tract, with mycoplasmas and ureaplasmas than are immunocompetent individuals. These micro-organisms are responsible for about two fifths of the septic arthritides occurring in these patients.
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无丙种球蛋白血症中的解脲支原体多发性关节炎。
DOI：
10.1097/00006454-198511000-00020
发表时间：
1985
期刊：
Pediatric infectious disease
影响因子：
--
作者：
Vogler,LB;Waites,KB;Wright,PF;Perrin,JM;Cassell,GH
通讯作者：
Cassell,GH
抗体缺乏的患者对支原体感染具有独特的易感性。
DOI：
--
发表时间：
1993
期刊：
Clinical infectious diseases : an official publication of the Infectious Diseases Society of America
影响因子：
--
作者：
Gelfand,EW
通讯作者：
Gelfand,EW
低丙种球蛋白血症患者的解脲支原体慢性骨髓炎。
DOI：
10.1016/0091-6749(91)90219-e
发表时间：
1991
期刊：
The Journal of allergy and clinical immunology
影响因子：
--
作者：
Mohiuddin,AA;Corren,J;Harbeck,RJ;Teague,JL;Volz,M;Gelfand,EW
通讯作者：
Gelfand,EW
低丙种球蛋白血症患者解脲脲原体化脓性关节炎的分子诊断。
影响因子：
--
作者：
Lee,AH;Ramanujam,T;Ware,P;Edelstein,PH;Brooks,JJ;Freundlich,B;SchumacherJr,HR;Zurier,RB;Weiner,DB;Williams,WV
通讯作者：
Williams,WV