Three-dimensional cavity-coupled metamaterials for plasmonic color and real-time colorimetric biosensors.
Three-dimensional cavity-coupled metamaterials for plasmonic color and real-time colorimetric biosensors.
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DOI：
10.1039/c9nr10343k
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发表时间：
2020-02
期刊：
影响因子：
6.7
通讯作者：
Jia Zhu;Guanzhou Lin;Yun Huang;Kenan Zhang;Meizhang Wu;Wengang Wu;Peimin Lu
中科院分区：
文献类型：
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作者：
Jia Zhu;Guanzhou Lin;Yun Huang;Kenan Zhang;Meizhang Wu;Wengang Wu;Peimin Lu
等离子体结构颜色通过简单的仪器甚至肉眼检测，在视觉生化传感方面具有巨大的潜力。在这里，我们提出了一种基于三维腔耦合超材料的生物素亲和素系统的折射率传感和检测的视觉和实时传感策略。这些超材料由顶部的金盘阵列、铝柱和底部的铝反射膜组成，具有类似于金属-绝缘体-金属结构的结构。绝缘层包括容易被气体或液体介质填充的气隙空腔。因此，分析物可以渗透到纳米级的空腔中，产生强烈的光-物质相互作用。传感器显示，折射率的任何微小变化都会引起明显的颜色变化，灵敏度达到每折射率单位683.5 nm，优值系数为3.5.当硫代化生物素和链霉亲和素的单分子层先后结合到纳米结构表面后，超材料的颜色从玫瑰红变为紫色。这一传感策略为方便地检测蛋白质、核酸和脂质提供了新的机会。
Plasmonic structure color has significant potential for visual biochemical sensing by simple instrumentation or even naked eye detection. Herein, we present a visual and real-time sensing strategy for refraction index sensing and detection of the biotin-avidin system based on three-dimensional cavity-coupled metamaterials. These metamaterials composed of a top array of gold disks, aluminium pillars and a bottom reflection film of aluminium have structures similar to the metal-insulator-metal structure. The insulating layer comprises air-gap cavities that are easily filled with gaseous or liquid dielectrics. Therefore, analytes can permeate into the nano-scale cavities and produce strong light-matter interactions. The sensor shows that any tiny change in the refraction index will induce a significant color variation and the sensitivity reaches 683.5 nm per refraction index unit with a figure of merit of 3.5. The color of the metamaterials changes from rose-red to violet and then loden after a monomolecular layer of thiolated biotin and streptavidin bind to the surface of the nanostructure successively. This sensing strategy offers new opportunities for the convenient detection of proteins, nucleic acids, and lipids.