Natural killer cell activity and head and neck cancer: a clinical assessment.
Natural killer cell activity and head and neck cancer: a clinical assessment.
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DOI：
10.1093/jnci/77.4.869
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发表时间：
1986-10
期刊：
影响因子：
--
通讯作者：
S. Schantz;E. Shillitoe;B. Brown;B. Campbell
中科院分区：
文献类型：
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作者：
S. Schantz;E. Shillitoe;B. Brown;B. Campbell
对127例上呼吸消化系统鳞状细胞癌患者进行了自然杀伤（NK）细胞功能的检测。注意到该癌症人群的平均溶解单位（LU）值小于同时评估的67名年龄匹配对照的平均值。细胞溶解功能的主要决定因素与肿瘤的生长模式有关。在局部或区域侵袭性更强的病变患者中观察到NK细胞功能增加，即，渗透到周围的解剖结构NK细胞应答的幅度也与循环IgG免疫球蛋白对单纯疱疹病毒1型相关抗原的量增加相关; IgG水平升高也与局部侵袭性病变相关。NK细胞活性在这些患者中的临床意义通过其与无病预后的关系来显示。NK活性升高的患者平均随访12个月，与其余人群的生存率相比，无病生存率有所改善。此外，NK LU值没有反映在标准分期方法中，这表明NK细胞功能的测量代表了头颈癌患者的独立预后参数。
In 127 patients with squamous cell carcinoma of the upper aerodigestive system, an assessment of natural killer (NK) cell function was performed. The mean lytic unit (LU) value of this cancer population was noted to be less than the mean value of 67 age-matched controls assessed concurrently. The major determinant of cytolytic function was related to the growth pattern of the tumor. Increased NK cell function was observed in patients with lesions that were more locally or regionally aggressive, i.e., that infiltrated surrounding anatomic structures. The magnitude of NK cell response also correlated with increased amounts of circulating IgG immunoglobulin to herpes simplex virus-type 1-associated antigens; elevated IgG levels were also associated with locally aggressive lesions. The clinical significance of NK cell activity in these patients is shown by its relationship to disease-free prognosis. Patients with elevated NK activity followed for a mean of 12 months had an improved disease-free survival as compared to the survival of the remaining population. Furthermore, NK LU values were not reflected in standard staging methods, which suggests that the measurement of NK cell function represents an independent prognostic parameter in the patient with head and neck cancer.