Integration of HIV-1 caused STAT3-associated B cell lymphoma in an AIDS patient
Integration of HIV-1 caused STAT3-associated B cell lymphoma in an AIDS patient
复制标题
DOI：
10.1016/j.micinf.2007.09.008
复制
发表时间：
2007-11-01
影响因子：
5.8
通讯作者：
Hoshino, Yoshihiko
中科院分区：
文献类型：
--
作者：
Katano, Harutaka;Sato, Yuko;Hoshino, Yoshihiko
信号转导和转录激活因子 3 (STAT3) 是一种 DNA 结合转录因子，可被多种细胞因子和干扰素激活。 STAT3 的高表达也与癌症和淋巴瘤有关。在这里，我们展示了一个 B 细胞淋巴瘤病例，其中有缺陷的人类免疫缺陷病毒 1 (HIV-1) 整合在第一个 STAT3 编码外显子的上游。具有间变性大细胞形态的淋巴瘤细胞在患有卡波西肉瘤的获得性免疫缺陷综合征（艾滋病）患者的肺部形成了多个结节性病变。原病毒具有 5' 长末端重复 (LTR) 删除，但在报告基因检测中，3' LTR 具有比 STAT3 启动子更强的启动子活性。免疫组织化学显示淋巴瘤细胞核中 STAT3 表达增加。 STAT3 的转染导致原代 B 细胞在体外发生短暂的细胞增殖。尽管这是一种非常罕见的 HIV-1 整合性淋巴瘤病例，但这些数据表明，HIV-1 整合引起的 STAT3 上调导致了这种特殊病例中 B 细胞淋巴瘤的发展。 (c) 2007 年 Elsevier Masson SAS。版权所有。
Signal transducer and activator of transcription 3 (STAT3) is a DNA-binding transcription factor activated by multiple cytokines and interferons. High expression of STAT3 has also been implicated in cancer and lymphoma. Here, we show a case of B cell lymphoma in which a defective human immunodeficiency virus 1 (HIV-1) integrated upstream of the first STAT3 coding exon. The lymphoma cells with anaplastic large cell morphology formed multiple nodular lesions in the lung of an acquired immunodeficiency syndrome (AIDS) patient with Kaposi's sarcoma. The provirus had a 5' long terminal repeat (LTR) deletion, but the 3' LTR had stronger promoter activity than the STAT3 promoter in reporter assays. Immunohistochemistry showed increased expression of STAT3 in the nuclei of lymphoma cells. Transfection of STAT3 resulted in transient cell proliferation in primary B cells in vitro. Although this is a very rare case of HIV-1-integrated lymphoma, these data suggest that up-regulation of STAT3 caused by HIV-1 integration resulted in the development of B cell lymphoma in this special case. (c) 2007 Elsevier Masson SAS. All rights reserved.