Chronic psychological stress enhances nociceptive processing in the urinary bladder in high-anxiety rats
Chronic psychological stress enhances nociceptive processing in the urinary bladder in high-anxiety rats
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DOI：
10.1016/j.physbeh.2007.04.009
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发表时间：
2007-08-15
影响因子：
2.9
通讯作者：
Ness, T. J.
中科院分区：
文献类型：
--
作者：
Robbins, M. T.;DeBerry, J.;Ness, T. J.
本研究旨在确定急性和/或慢性心理应激是否会引起膀胱痛觉的改变。雌性Sprague-Dawley （SD；低/中度焦虑）或Wistar-Kyoto （WK；高焦虑）大鼠暴露于急性（1天）或慢性（10天）避水应激范式或假应激范式。在基线和最终应激或假应激暴露后，对机械和热刺激和粪便颗粒输出的爪退出阈值进行量化。然后给大鼠注射镇静剂，记录其对膀胱膨胀（UBD）的内脏运动反应（VMRs）。虽然急性应激暴露没有显著改变两种大鼠的膀胱伤害反应，但暴露于慢性应激范式的WK大鼠对UBD的反应增强。这些高焦虑大鼠在急性而非慢性应激后也表现出躯体性镇痛。此外，应激时，WK大鼠的粪便颗粒排出量高于SD大鼠。SD大鼠对机械刺激的伤害性反应发生了显著的应激性变化。慢性心理应激仅在高焦虑大鼠中显著增强膀胱伤害反应，这进一步支持了遗传、压力和焦虑在疼痛性泌尿生殖疾病（如间质性膀胱炎（IC））中的关键作用。(C) 2007年Elsevier Inc.出版
This study sought to determine whether acute and/or chronic psychological stress produce changes in urinary bladder nociception. Female Sprague-Dawley (SD; low/moderate anxiety) or Wistar-Kyoto (WK; high-anxiety) rats were exposed to either an acute (I day) or a chronic (10 days) water avoidance stress paradigm or a sham stress paradigm. Paw withdrawal thresholds to mechanical and thermal stimuli and fecal pellet output, were quantified at baseline and after the final stress or sham stress exposure. Rats were then sedated, and visceromotor responses (VMRs) to urinary bladder distension (UBD) were recorded. While acute stress exposure did not significantly alter bladder nociceptive responses in either strain of rats, WK rats exposed to a chronic stress paradigm exhibited enhanced responses to UBD. These high-anxiety rats also exhibited somatic analgesia following acute, but not chronic, stress. Furthermore, WK rats had greater fecal pellet output than SD rats when stressed. Significant stress-induced changes in nociceptive responses to mechanical stimuli were observed in SD rats. That chronic psychological stress significantly enhanced bladder nociceptive responses only in high-anxiety rats provides further support for a critical role of genetics, stress and anxiety as exacerbating factors in painful urogenital disorders such as interstitial cystitis (IC). (C) 2007 Published by Elsevier Inc.