Unlocking the Secrets of Mitochondria in the Cardiovascular System Path to a Cure in Heart Failure-A Report from the 2018 National Heart, Lung, and Blood Institute Workshop
Unlocking the Secrets of Mitochondria in the Cardiovascular System Path to a Cure in Heart Failure-A Report from the 2018 National Heart, Lung, and Blood Institute Workshop
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DOI：
10.1161/circulationaha.119.040551
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发表时间：
2019-10-01
期刊：
影响因子：
37.8
通讯作者：
Longacre, Lisa Schwartz
中科院分区：
文献类型：
--
作者：
Tian, Rong;Colucci, Wilson S.;Longacre, Lisa Schwartz
线粒体已成为心力衰竭和其他心血管疾病的发病机制和进展的核心因素，但没有治疗线粒体功能障碍的疗法。国家心脏，肺和血液研究所于2018年8月召集了一组心力衰竭，心血管疾病和线粒体研究的领先专家。这些专家回顾了当前的科学状况，并确定了基础，转化和临床研究中的关键差距和机会，重点关注基于心功能不全的治疗策略的潜力。该研讨会提供了短期和长期的建议，以推动该领域的临床战略，预防和治疗心力衰竭和心血管疾病，通过使用基于心血管的方法。
Mitochondria have emerged as a central factor in the pathogenesis and progression of heart failure, and other cardiovascular diseases, as well, but no therapies are available to treat mitochondrial dysfunction. The National Heart, Lung, and Blood Institute convened a group of leading experts in heart failure, cardiovascular diseases, and mitochondria research in August 2018. These experts reviewed the current state of science and identified key gaps and opportunities in basic, translational, and clinical research focusing on the potential of mitochondria-based therapeutic strategies in heart failure. The workshop provided short- and long-term recommendations for moving the field toward clinical strategies for the prevention and treatment of heart failure and cardiovascular diseases by using mitochondria-based approaches.