Encoding of the cough reflex in anesthetized guinea pigs
Encoding of the cough reflex in anesthetized guinea pigs
复制标题
DOI：
10.1152/ajpregu.00044.2010
复制
发表时间：
2011-02-01
影响因子：
2.8
通讯作者：
Mori, Nanako
中科院分区：
文献类型：
--
作者：
Canning, Brendan J.;Mori, Nanako
Canning BJ，Mori N.麻醉豚鼠咳嗽反射的编码。Am J Physiol Regul Integr Comp Physiol 300：R369-R377，2011年。首次发表于2010年10月6日; doi：10.1152/ajpregu.00044.2010.-我们先前已经描述了咳嗽受体的生理和形态学特性及其在气道和孤束核（NTS）中的终止位点。在本研究中，我们提出了咳嗽受体的初级中枢突触在编码咳嗽中起重要作用的假设。我们发现咳嗽需要持续的高频（>= 8 Hz）传入神经激活。我们还发现了促进（求和，致敏）和抑制咳嗽起始的过程的证据。咳嗽的致敏作用伴随着咳嗽受体的重复阈下激活或通过C纤维和/或nTS神经激肽受体激活的同时激活而发生。由重复和/或连续传入神经激活诱发的咳嗽脱敏具有快速发作（
Canning BJ, Mori N. Encoding of the cough reflex in anesthetized guinea pigs. Am J Physiol Regul Integr Comp Physiol 300: R369-R377, 2011. First published October 6, 2010; doi: 10.1152/ajpregu.00044.2010.-We have previously described the physiological and morphological properties of the cough receptors and their sites of termination in the airways and centrally in the nucleus tractus solitarius (nTS). In the present study, we have addressed the hypothesis that the primary central synapses of the cough receptors subserve an essential role in the encoding of cough. We found that cough requires sustained, high-frequency (>= 8-Hz) afferent nerve activation. We also found evidence for processes that both facilitate (summation, sensitization) and inhibit the initiation of cough. Sensitization of cough occurs with repetitive subthreshold activation of the cough receptors or by coincident activation of C-fibers and/or nTS neurokinin receptor activation. Desensitization of cough evoked by repetitive and/or continuous afferent nerve activation has a rapid onset (