Tackling human and animal health threats through innovative vaccinology in Africa.
Tackling human and animal health threats through innovative vaccinology in Africa.
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DOI：
10.12688/aasopenres.12877.1
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发表时间：
2018-07-02
影响因子：
--
通讯作者：
Charleston, Bryan
中科院分区：
文献类型：
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作者：
Warimwe, George M;Purushotham, Jyothi;Charleston, Bryan
非洲首当其冲地受到世界上许多最具破坏性的人类和动物传染病的影响，其中许多疾病没有获得许可或有效的疫苗。然而，非洲大陆针对这些全球健康威胁采取新干预措施的潜力在很大程度上尚未得到开发。加强非洲疫苗研发部门可以加快发现、开发和部署针对当地流行的传染病的有效对策，其中许多传染病被忽视，并有能力传播到新的地理环境。在这里，我们回顾了非洲的人类和兽用疫苗研发部门，并确定了应该优先投资的关键领域，以及可以从非洲兽用疫苗行业获得的协同效应，该行业出人意料地强大，与人类疫苗研发有着密切的相似之处。
Africa bears the brunt of many of the world's most devastating human and animal infectious diseases, a good number of which have no licensed or effective vaccines available. The continent's potential to generate novel interventions against these global health threats is however largely untapped. Strengthening Africa's vaccine research and development (R&D) sector could accelerate discovery, development and deployment of effective countermeasures against locally prevalent infectious diseases, many of which are neglected and have the capacity to spread to new geographical settings. Here, we review Africa's human and veterinary vaccine R&D sectors and identify key areas that should be prioritized for investment, and synergies that could be exploited from Africa's veterinary vaccine industry, which is surprisingly strong and has close parallels with human vaccine R&D.