EXPERIMENTAL INFECTION OF CHIMPANZEES WITH HUMAN RHINOVIRUS TYPES 14 AND 43
EXPERIMENTAL INFECTION OF CHIMPANZEES WITH HUMAN RHINOVIRUS TYPES 14 AND 43
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DOI：
10.3181/00379727-127-32875
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发表时间：
1968-01-01
影响因子：
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通讯作者：
DICK, EC
中科院分区：
文献类型：
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作者：
DICK, EC
在3个系列实验中，没有特异性中和抗体的黑猩猩感染了14型和43型鼻病毒。虽然受感染的动物在6至21天内释放病毒并产生高水平的特异性抗体，但临床疾病不明显。在血清中和抗体仍然存在的情况下，黑猩猩用相同的试剂再次攻击，在不到5小时的时间内就会脱落病毒。这是第一个成功的非人类鼻病毒感染的实验报告。
In 3 serial experiments, chimpanzees free of specific neutralizing antibody were infected with rhinovirus types 14 or 43. Although infected animals shed virus from 6 to 21 days and produced high levels of specific antibody, clinical illness was not discernible. Providing serum neutralizing antibody was still present, chimpanzees rechallenged with the same agent shed virus for less than 5 hours. This is the first report of successful experimental infection by human rhinoviruses of species other than man.