Study protocol of the MUSED study: A randomized controlled trial to evaluate the psychobiological effects of group music therapy in women with depression
Study protocol of the MUSED study: A randomized controlled trial to evaluate the psychobiological effects of group music therapy in women with depression
复制标题
MUSED研究方案：一项评估集体音乐治疗对抑郁症妇女心理生物学影响的随机对照试验
DOI：
10.1080/08098131.2020.1760921
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发表时间：
2020-06-17
影响因子：
1.6
通讯作者：
Warth, Marco
中科院分区：
文献类型：
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作者：
Gaebel, Christine;Rittner, Sabine;Warth, Marco
简介 患有抑郁症的人通常表现出情绪调节受损，并伴有心理生物应激系统调节缺陷。初步研究表明，音乐疗法可以影响抑郁症状和心理生物学机制，因此可能有助于有效治疗抑郁症。我们将研究音乐疗法对抑郁症状的影响。此外，我们将研究这种疗法对日常生活中昼夜节律的影响。特别是，我们将在生态瞬时评估（EMA）的框架内监测迷走神经张力的昼夜节律（以心率变异性（HRV）为索引）和下丘脑-垂体-肾上腺（HPA）轴（以昼夜皮质醇曲线为索引）。方法 74 名年龄在 18-65 岁之间、被诊断患有抑郁症或心境恶劣的女性有资格参加。参与者将被随机分配到干预组（10 周音乐治疗 + 照常治疗，TAU）或对照组（仅 TAU）。自我报告数据将在干预期之前和之后以及评估后10周后收集。将在干预期之前和之后收集心理生物学数据（48 小时 HRV、连续两天各六个样本的唾液皮质醇）和观察者评分。讨论 该研究旨在验证之前的研究结果，即音乐疗法可有效治疗抑郁症。研究结果将促进人们对音乐疗法如何影响 HPA 轴和自主调节过程的理解。 EMA 方法提供了测试日常生活中不同心理生物学标记之间协方差的潜力。
Introduction People suffering from depression commonly show impaired emotion regulation, accompanied by deficits in the regulation of psychobiological stress systems. Initial studies indicate that music therapy can impact depressive symptoms and psychobiological mechanisms, and may therefore contribute to effective treatment for depression. We will investigate the effects of music therapy on depressive symptoms. Moreover, we will examine the impact of this therapy on circadian biological rhythms in daily life. In particular, we will monitor the circadian rhythm of vagal tone, indexed by heart rate variability (HRV), and of the hypothalamic-pituitary-adrenal (HPA) axis, indexed by the diurnal cortisol profile, within the framework of ecological momentary assessment (EMA). Method Seventy-four women aged 18-65 years with a diagnosis of depression or dysthymia will be eligible for participation. Participants will be randomly assigned to the intervention group (10 weeks music therapy + treatment as usual, TAU) or the control group (TAU only). Self-report data will be collected before and after the intervention period, and 10 weeks after the post-assessment. Psychobiological data (48 hours HRV, salivary cortisol from six samples each of two consecutive days) and observer ratings will be gathered before and after the intervention period. Discussion The study aims to validate previous findings that music therapy is effective in the treatment of depression. The results will foster the understanding of how music therapy affects HPA axis and autonomic regulation processes. The EMA approach offers the potential to test for covariance between different psychobiological markers in daily life.