Comparative evaluation of the efficacy of synthetic nanocrystalline hydroxyapatite bone graft (Ostim(®)) and synthetic microcrystalline hydroxyapatite bone graft (Osteogen(®)) in the treatment of human periodontal intrabony defects: A clinical and denta scan study.
Comparative evaluation of the efficacy of synthetic nanocrystalline hydroxyapatite bone graft (Ostim(®)) and synthetic microcrystalline hydroxyapatite bone graft (Osteogen(®)) in the treatment of human periodontal intrabony defects: A clinical and denta scan study.
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DOI：
10.4103/0972-124x.184036
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发表时间：
2016-07
影响因子：
--
通讯作者：
Gupta H
中科院分区：
文献类型：
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作者：
Kamboj M;Arora R;Gupta H
旨在通过牙科扫描在临床和放射学上评估合成纳米晶羟基磷灰石 (HA) (Ostim®) 和微晶 HA (Osteogen®) 骨移植物在临床和放射学治疗人类牙周骨内缺陷中的相对功效。随机选取 10 例年龄低于 55 岁、双侧骨内牙周缺损深度≥2 mm 的慢性牙周炎患者，采用合成纳米晶 HA (Ostim®) 或合成微晶 HA (Osteogen®) 骨移植治疗。使用咬合丙烯酸支架在术前和术后 3 个月和 6 个月测量临床参数，包括探诊深度 (PD) 和临床附着水平 (CAL)。术前和术后 6 个月时借助牙科扫描测量放射线参数。治疗后 6 个月，Osteogen® 组的平均 PD 从 11.10 ± 1.663 降低至 8.50 ± 0.850 mm，平均 CAL 从 6.30 ± 1.160 降低至 3.40 ± 0.516 mm，而 Ostim® 组的平均 PD 从 11.20 ± 0.919 降低至 8.30 ± 0.823 毫米，平均 CAL 从 6.10 ± 0.738 降至 3.30 ± 0.483 毫米。治疗后 6 个月时，牙科扫描显示 Osteogen® 组的平均骨内缺损深度从 2.54 ± 0.786 毫米减少到 1.01 ± 0.448 毫米，而 Ostim® 组则从 2.71 ± 0.650 毫米减少到 1.12 ± 0.563 毫米。结论是，无论其物理化学特性如何，两种HA骨移植物都产生了统计上显着的袋深度、骨病变深度的减少，以及统计上显着的附着水平的增加。
To evaluate the relative efficacy of synthetic nanocrystalline hydroxyapatite (HA) (Ostim®) and microcrystalline HA (Osteogen®) bone grafts in the treatment of human periodontal intrabony defects clinically and radiographically through denta scan. Ten chronic periodontitis patients with bilateral intrabony periodontal defects of ≥2 mm radiographic defect depth below 55 years of age were selected randomly and treated with synthetic nanocrystalline HA (Ostim®) or synthetic microcrystalline HA (Osteogen®) bone graft. Clinical parameters including probing depth (PD) and clinical attachment level (CAL) were measured preoperatively and postoperatively at 3 and 6 months for each of the defects using an occlusal acrylic stent. Radiographic parameters were measured with the help of denta scan preoperatively and postoperatively at 6 months. At 6 months following therapy, the Osteogen® group showed a reduction in mean PD from 11.10 ± 1.663 to 8.50 ± 0.850 mm and a change in mean CAL from 6.30 ± 1.160 to 3.40 ± 0.516 mm, whereas in the Ostim® group, the mean PD decreased from 11.20 ± 0.919 to 8.30 ± 0.823 mm and mean CAL decreased from 6.10 ± 0.738 to 3.30 ± 0.483 mm. At 6 months following therapy, denta scan showed a reduction in mean intrabony defect depth in the Osteogen® group from 2.54 ± 0.786 to 1.01 ± 0.448 mm, whereas in the Ostim® group, it was 2.71 ± 0.650 mm to 1.12 ± 0.563 mm. It was concluded that both the HA bone grafts produced statistically significant reduction in pocket depth, in the depth of osseous lesion, and a statistically significant gain in attachment level, irrespective of their physico-chemical properties.