Study of neurovascular coupling by modulating neuronal activity with GABA.
Study of neurovascular coupling by modulating neuronal activity with GABA.
复制标题
通过用 GABA 调节神经元活动来研究神经血管耦合。
DOI：
10.1016/j.brainres.2010.11.082
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发表时间：
2011
期刊：
影响因子：
2.9
通讯作者：
Franceschini,MariaAngela
中科院分区：
文献类型：
--
作者：
Radhakrishnan,Harsha;Wu,Weicheng;Boas,David;Franceschini,MariaAngela
今天的Web服务由TCP流主导，这些流非常短，以至于它们在握手后终止了几个往返;这种握手是这种流的延迟的重要来源。在本文中，我们描述的设计，实现和部署的TCP快速开放协议，一种新的机制，使数据交换在TCP的初始握手。这样，TCP Fast Open将应用程序网络延迟减少了一个完整的往返时间，减少了如此短的TCP传输所经历的延迟。我们解决了在三次握手期间允许数据交换所固有的安全问题，我们使用验证IP地址所有权的安全令牌来缓解这些问题。我们详细介绍了其他回退防御机制，并解决了我们面临的中间盒问题，现有网络堆栈的向后兼容性和增量部署。基于流量分析和网络仿真，我们表明，TCP快速打开将减少HTTP事务的网络延迟的15%和整个页面的加载时间平均超过10%，在某些情况下高达40%。
Today's web services are dominated by TCP flows so short that they terminate a few round trips after handshaking; this handshake is a significant source of latency for such flows. In this paper we describe the design, implementation, and deployment of the TCP Fast Open protocol, a new mechanism that enables data exchange during TCP's initial handshake. In doing so, TCP Fast Open decreases application network latency by one full round-trip time, decreasing the delay experienced by such short TCP transfers.We address the security issues inherent in allowing data exchange during the three-way handshake, which we mitigate using a security token that verifies IP address ownership. We detail other fall-back defense mechanisms and address issues we faced with middleboxes, backwards compatibility for existing network stacks, and incremental deployment. Based on traffic analysis and network emulation, we show that TCP Fast Open would decrease HTTP transaction network latency by 15% and whole-page load time over 10% on average, and in some cases up to 40%.