Advancing cancer treatment: in vivo delivery of therapeutic small noncoding RNAs.
Advancing cancer treatment: in vivo delivery of therapeutic small noncoding RNAs.
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DOI：
10.3389/fmolb.2023.1297413
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发表时间：
2023
影响因子：
5
通讯作者：
中科院分区：
文献类型：
--
作者：
近年来，小的非编码RNA（ncRNA）已经成为癌症治疗领域的新角色。它们直接调节遗传网络和靶向癌基因的独特能力使其成为现有小分子药物的宝贵补充。同时，基于小ncRNA的治疗剂的进步重新点燃了对有效体内递送策略的追求。在这篇综述中，我们提供了最新的临床和临床前研究领域的小ncRNA为基础的癌症治疗的概述。此外，我们揭示了阻碍这些有前途的疗法成功转化为临床实践的关键挑战，特别关注递送方法，旨在刺激创新方法来解决癌症治疗的这一基础方面。
In recent years, small non-coding RNAs (ncRNAs) have emerged as a new player in the realm of cancer therapeutics. Their unique capacity to directly modulate genetic networks and target oncogenes positions them as valuable complements to existing small-molecule drugs. Concurrently, the advancement of small ncRNA-based therapeutics has rekindled the pursuit of efficacious in vivo delivery strategies. In this review, we provide an overview of the most current clinical and preclinical studies in the field of small ncRNA-based cancer therapeutics. Furthermore, we shed light on the pivotal challenges hindering the successful translation of these promising therapies into clinical practice, with a specific focus on delivery methods, aiming to stimulate innovative approaches to address this foundational aspect of cancer treatment.
影响因子：
3.7
作者：
Sheng, Shuyan;Su, Wenzhuo;Mao, Deshen;Li, Conghan;Hu, Xinyang;Deng, Wanyu;Yao, Yong;Ji, Yongsheng
通讯作者：
Ji, Yongsheng