Remnant lipoproteins are related to intima-media thickness of the carotid artery independently of LDL cholesterol and plasma triglycerides.
Remnant lipoproteins are related to intima-media thickness of the carotid artery independently of LDL cholesterol and plasma triglycerides.
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发表时间：
2001
影响因子：
6.5
通讯作者：
F. Karpe;S. Boquist;Rong Tang;Gene M. Bond;U. Faire;Anders Hamsten
中科院分区：
文献类型：
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作者：
F. Karpe;S. Boquist;Rong Tang;Gene M. Bond;U. Faire;Anders Hamsten
富含甘油三酸酯的脂蛋白（TRL）的残留物与动脉粥样硬化的早期发展有关。我们通过在健康50岁的男性中量化残余颗粒胆固醇（RLP-C）的血浆浓度来检验了这一假设，其中B通过B评估了公共颈动脉内膜膜厚度（CCA-IMT）。 - 模式超声作为动脉粥样硬化的替代标记。在餐后脂肪血症期间，对受试者进行了富裕的餐食，以研究RLP-C的产生。两次确定空腹血浆RLP-C和其他主要的禁食血浆脂质和脂蛋白两次，并且平均RLP-C浓度与CCA-IMT密切相关（r = 0.32，p = 0.002）。另外，低密度脂蛋白（LDL）胆固醇（r = 0.25，p = 0.01）和血浆甘油三酸酯（r = 0.20，p = 0.05）与CCA-IMT显着相关。多元分析显示RLP-C对CCA-IMT的甘油三酸酯无关贡献。脂肪摄入后，中位血浆RLP-C浓度在3小时后加倍。该增加与餐后TRL载脂蛋白（APO）B-48和大型（S（f）60; -400）TRL APOB-100密切相关。对于3-H RLP-C水平，与CCA-IMT的缔合相比，对于空腹RLP-C浓度[r = 0.27，p <0.01（3 h），而r = 0.22，p <0.05（0 h） ）。我们得出的结论是，在健康的中年男性中，RLP-C的血浆浓度与CCA-IMT有关，与血浆甘油三酸酯和LDL胆固醇无关。 -Karpe，F.，S。Boquist，R。Tang，G。M。Bond，U。DeFaire和A. Hamsten。残留的脂蛋白与与LDL胆固醇和血浆甘油三酸酯独立于颈动脉的内膜膜厚度有关。 J. Lipid Res。 2001。42：17; -21。
Remnants of triglyceride-rich lipoproteins (TRL) have been implicated in the early development of atherosclerosis. We tested this hypothesis by quantifying the plasma concentration of remnant-like particle cholesterol (RLP-C) in a cohort of healthy 50-year-old men in whom the common carotid artery intima-media thickness (CCA-IMT) was assessed by B-mode ultrasound as a surrogate marker for atherosclerosis. The subjects were given a fat-rich meal to study the generation of RLP-C during postprandial lipemia. Fasting plasma RLP-C and other major fasting plasma lipids and lipoproteins were determined twice, and the mean RLP-C concentration was strongly correlated with CCA-IMT (r = 0.32, P = 0.002). In addition, low density lipoprotein (LDL) cholesterol (r = 0.25, P = 0.01) and plasma triglycerides (r = 0.20, P = 0.05) were significantly related to CCA-IMT. Multivariate analyses showed a triglyceride-independent contribution of RLP-C to CCA-IMT. After fat intake, the median plasma RLP-C concentration was doubled after 3 h. The increase was strongly related to the postprandial generation of TRL apolipoprotein (apo)B-48, and large (S(f) 60;-400) TRL apoB-100. The association with CCA-IMT was somewhat stronger for the 3-h RLP-C level than for the fasting RLP-C concentration [r = 0.27, P < 0.01 (3 h) compared with r = 0.22, P < 0.05 (0 h)]. We conclude that the plasma concentration of RLP-C is related to CCA-IMT, independent of plasma triglycerides and LDL cholesterol, in a healthy middle-aged male population. - Karpe, F., S. Boquist, R. Tang, G. M. Bond, U. de Faire, and A. Hamsten. Remnant lipoproteins are related to intima-media thickness of the carotid artery independently of LDL cholesterol and plasma triglycerides. J. Lipid Res. 2001. 42: 17;-21.