Phellinus linteus Extract Exerts Anti-asthmatic Effects by Suppressing NF-κB and p38 MAPK Activity in an OVA-induced Mouse Model of Asthma.
Phellinus linteus Extract Exerts Anti-asthmatic Effects by Suppressing NF-κB and p38 MAPK Activity in an OVA-induced Mouse Model of Asthma.
复制标题
DOI：
10.4110/in.2014.14.2.107
复制
发表时间：
2014-04
期刊：
影响因子：
6
通讯作者：
Choi YH
中科院分区：
文献类型：
--
作者：
Yan GH;Choi YH
在亚洲国家中，马兜铃一直被用作传统草药，并且已知具有抗肿瘤、免疫调节、抗炎和抗过敏活性。然而，P. linteus对实验性哮喘的保护作用尚未得到充分研究。本研究的目的是确定P. linteus乙醇提取物（PLE）是否抑制OVA诱导的哮喘模型中的炎症反应。正如预期的那样，PLE口服给药可显着抑制卵蛋白A攻击的小鼠的嗜酸性气道炎症和气道高反应性。支持这些数据，增加的Th 2细胞因子（IL-4，IL-5和IL-13），嗜酸性粒细胞趋化因子，粘附分子在肺组织和支气管肺泡灌洗液吸入OVA后显着衰减PLE。PLE还能抑制OVA诱导的肺组织NF-κB和p38 MAPK的活化。因此，我们的研究结果表明，P. linteus作为哮喘治疗药物的潜力。
Phellinus linteus has been used as a traditional herbal medicine in Asian countries and is known to have anti-tumor, immunomodulatory, anti-inflammatory, and anti-allergic activities. However, the protective effects of P. linteus against experimental asthma have not been fully investigated. The objective of this study was to determine whether P. linteus ethanol extract (PLE) suppresses inflammatory response in an OVA-induced asthma model. As expected, the oral administration of PLE significantly inhibited eosinophilic airway inflammation and airway hyperresponsiveness in OVA-challenged BALB/c mice. Supporting these data, the augmentation of Th2 cytokines (IL-4, IL-5, and IL-13), eotaxin, and adhesion molecules in lung tissues and bronchoalveolar lavage fluid after OVA inhalation was markedly attenuated by PLE. Furthermore, PLE reduced OVA-induced activation of NF-κB and p38 MAPK in lung tissues. Therefore, our results suggest the potential of P. linteus as a therapeutic agent for asthma.