Eurocristatine, a new diketopiperazine dimer from the marine sponge-associated fungus Eurotium cristatum
Eurocristatine, a new diketopiperazine dimer from the marine sponge-associated fungus Eurotium cristatum
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DOI：
10.1016/j.phytol.2012.07.010
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发表时间：
2012-12-01
影响因子：
1.7
通讯作者：
Kijjoa, Anake
中科院分区：
文献类型：
--
作者：
Gomes, Nelson M.;Dethoup, Tida;Kijjoa, Anake
从海绵相关真菌Eurotium cristatum KUFC 7356的培养物中分离到8种已知代谢产物，包括蒽醌类红血球素、物理素、catenarin、大黄素和二氧哌嗪类生物碱echinulin、neoechinulin A、neoechinulin E、variecolorin J，并分离到新的二酮哌嗪二聚体eurocristatine(1)。eurocristatine(1)的结构通过1D和2D NMR波谱分析以及hresms建立，并通过x射线晶体学分析确定其立体碳的绝对构型。Eurocristatine(1)不表现出细胞毒性、抗菌或抗真菌活性。(C) 2012年欧洲植物化学学会。Elsevier B.V.版权所有。
A new diketopiperazine dimer, eurocristatine (1), was isolated, in addition to eight known metabolites including the anthraquinones erythroglaucin, physcion, catenarin, emodin and the dioxopiperazine alkaloids echinulin, neoechinulin A, neoechinulin E, variecolorin J, from the culture of the sponge-associated fungus Eurotium cristatum KUFC 7356. The structure of eurocristatine (1) was established based on 1D and 2D NMR spectral analysis as well as HRESIMS, and the absolute configuration of its stereogenic carbons was determined by an X-ray crystallographic analysis. Eurocristatine (1) did not exhibit cytotoxic, antibacterial or antifungal activity. (C) 2012 Phytochemical Society of Europe. Published by Elsevier B.V. All rights reserved.