Fluorescence spectral characteristics and fluorescence decay profiles of covalent polycyclic aromatic carcinogen-DNA adducts.
Fluorescence spectral characteristics and fluorescence decay profiles of covalent polycyclic aromatic carcinogen-DNA adducts.
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共价多环芳香族致癌物-DNA 加合物的荧光光谱特征和荧光衰减曲线。
DOI：
10.1007/978-1-4684-8041-2_21
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发表时间：
1989
期刊：
影响因子：
--
通讯作者：
Sutherland,JC
中科院分区：
文献类型：
--
作者：
Kim,SK;Geacintov,NE;Zinger,D;Sutherland,JC
已知许多多环芳烃（PAH）具有致突变性和致癌性。PAH化合物的结构、物理化学性质和生物活性差异之间的关系长期以来一直是化学家着迷的来源（Lehr等人，1985; Harvey和Geacintov，1988）。在活细胞中，微溶且相对惰性的PAH分子通过代谢转化为各种含氧衍生物（Conney，1982年审查）;在许多不同实验室获得的结果表明，PAH化合物的最终致突变和致瘤形式是二醇环氧衍生物。
Many polycyclic aromatic hydrocarbons (PAH) are known to be mutagenic and carcinogenic. The relationships between structure, physico-chemical properties, and differences in biological activities of PAH compounds, have long been a source of fascination to chemists (Lehr et al., 1985; Harvey and Geacintov, 1988). In living cells, the sparingly soluble and relatively inert PAH molecules are metabolically converted to a variety of oxygenated derivatives (reviewed by Conney, 1982); results obtained in many different laboratories indicate that the ultimate mutagenic and tumorigenic forms of PAH compounds are diol epoxide derivatives.