Fiber orientation measurements by diffusion tensor imaging improve hydrogen-1 magnetic resonance spectroscopy of intramyocellular lipids in human leg muscles.
Fiber orientation measurements by diffusion tensor imaging improve hydrogen-1 magnetic resonance spectroscopy of intramyocellular lipids in human leg muscles.
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通过扩散张量成像进行的纤维取向测量改善了人类腿部肌肉中肌细胞内脂质的氢 1 磁共振波谱。
DOI：
10.1117/1.jmi.2.2.026002
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发表时间：
2015
期刊：
影响因子：
--
通讯作者：
Clarke,GeoffreyD
中科院分区：
文献类型：
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作者：
Valaparla,SunilK;Gao,Feng;Daniele,Giuseppe;Abdul-Ghani,Muhammad;Clarke,GeoffreyD
12名健康受试者接受氢-1磁共振波谱（）采集（）、弥散张量成像（DTI）（a值为）和脂肪-水磁共振成像（MRI）（使用狄克逊方法）。受试者特定的肌纤维方向，来自DTI，被用来估计脂质质子光谱化学位移。在股外侧肌（VL）、比目鱼肌（SO）和胫骨前肌（TA）中测量的羽角分别为23.78度、17.06度和8.49度，导致肌细胞外脂质（EMCL）和肌细胞内脂质（IMCL）之间的化学位移分别为0.15、0.17和0.19 ppm。SO、VL和TA的IMCL浓度分别为、、和。在SO、VL和TA的IMCL和EMCL成对比较中观察到显著差异（）。在VL（）、SO（）和TA（）的总脂肪分数与狄克逊MRI之间观察到强相关性。脂肪分数（FFMR和FFMRI）之间的Bland-Altman分析显示了良好的一致性，一致性限（LoA）较小：VL（LoA：至0.69%），SO（LoA：至1.33%），TA（LoA：至0.47%）。这项研究的结果表明，在这三种骨骼肌类型的肌纤维取向和脂质浓度的变化。
Twelve healthy subjects underwent hydrogen-1 magnetic resonance spectroscopy () acquisition (), diffusion tensor imaging (DTI) with a-value of, and fat-water magnetic resonance imaging (MRI) using the Dixon method. Subject-specific muscle fiber orientation, derived from DTI, was used to estimate the lipid proton spectral chemical shift. Pennation angles were measured as 23.78 deg in vastus lateralis (VL), 17.06 deg in soleus (SO), and 8.49 deg in tibialis anterior (TA) resulting in a chemical shift between extramyocellular lipids (EMCL) and intramyocellular lipids (IMCL) of 0.15, 0.17, and 0.19 ppm, respectively. IMCL concentrations were,, andin SO, VL, and TA, respectively. Significant differences were observed in IMCL and EMCL pairwise comparisons in SO, VL, and TA (). Strong correlations were observed between total fat fractions fromand Dixon MRI for VL (), SO (), and TA (). Bland-Altman analysis between fat fractions (FFMRSand FFMRI) showed good agreement with small limits of agreement (LoA):(LoA:to 0.69%) in VL,(LoA:to 1.33%) in SO, and(LoA:to 0.47%) in TA. The results of this study demonstrate the variation in muscle fiber orientation and lipid concentrations in these three skeletal muscle types.