Genotype 4 Hepatitis E virus replicates in the placenta, causes severe histopathological damage, and vertically transmits to fetuses
Genotype 4 Hepatitis E virus replicates in the placenta, causes severe histopathological damage, and vertically transmits to fetuses
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DOI：
10.1016/j.jinf.2023.05.003
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发表时间：
2023-06-07
影响因子：
28.2
通讯作者：
Huang, Fen
中科院分区：
文献类型：
--
作者：
Qian, Zhongyao;Li, Tengyuan;Huang, Fen
背景资料：孕妇戊型肝炎病毒（HEV）感染会导致不良妊娠结局，包括孕产妇死亡、早产、死产和胎儿感染。方法：收集HEV-4感染孕妇的胎盘及胎盘附件，探讨HEV母婴垂直传播的可能性。结果：HEV-4可在胎盘、胎盘膜和脐带中复制，经母婴垂直传播。HEV-4胎盘感染导致严重的组织病理学损伤，如纤维化和钙化，以及严重的炎症反应。在38.5%的HEV-4感染孕妇中观察到不良的母体结局。不同的细胞因子/趋化因子表达模式的HEV感染的孕妇和非孕妇可能有助于不良妊娠结局。此外，母亲和胎儿对HEV-4的先天免疫应答受损，促进了妊娠期间的病毒复制。结论：HEV-4在胎盘内复制，经母婴垂直传播，可引起严重的组织病理学损害。COPY; 2023英国感染协会。由爱思唯尔有限公司出版。保留所有权利。
Background: Hepatitis E virus (HEV) infection in pregnant women causes adverse pregnancy outcomes, including maternal death, premature delivery, stillbirth, and fetal infection. However, the pathogenesis of maternal and fetal HEV infection is unclear.Methods: Placenta and placental appendixes were collected from HEV-4 infected pregnant women to explore the vertical transmission of HEV from mothers to fetuses. Results: HEV-4 replicated in the placenta, placental membrane, and umbilical cord and was vertically transmitted from mothers to fetuses. HEV-4 placental infection resulted in serious histopathological damage, such as fibrosis and calcification, and severe inflammatory responses. Adverse maternal outcomes were observed in 38.5% of HEV-4 infected pregnant women. The distinct cytokine/chemokine expression patterns of HEV-infected pregnant women and nonpregnant women may contribute to the adverse pregnancy outcomes. Furthermore, the impaired maternal and fetal innate immune responses against HEV-4 facilitated viral replication during pregnancy. Conclusion: HEV-4 replicates in the placenta and is vertically transmitted from mothers to fetuses, causing severe histopathological damage.& COPY; 2023 The British Infection Association. Published by Elsevier Ltd. All rights reserved.