Optimizing breast cancer treatment efficacy with intensity-modulated radiotherapy
Optimizing breast cancer treatment efficacy with intensity-modulated radiotherapy
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DOI：
10.1016/s0360-3016(02)03746-x
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发表时间：
2002-12-01
影响因子：
7
通讯作者：
Wong, J
中科院分区：
文献类型：
--
作者：
Vicini, FA;Sharpe, M;Wong, J
目的：介绍我们的临床经验，使用调强放射治疗（IMRT），以提高剂量均匀性和治疗效果的早期乳腺癌患者进行乳房保护therapy.Methods和材料：共281例患者的0期，I期和II期乳腺癌乳腺癌治疗的保留乳房接受全乳房RT肿块切除术后，使用我们的静态，多叶准直器（sMLC）IMRT技术。分析了在临床上大规模实施这项技术的技术和实践方面。用这种技术治疗的患者的临床结果也review.Results：三维对齐的切向字段和剂量IMRT计划所需的中位时间分别为40和45分钟。每例患者满足预定义剂量体积限制所需的sMLC节段的中位数为6（范围3-12）。开放野（无sMLC节段）治疗的中位百分比为83%（范围38-96%），中位治疗时间为
Purpose: To present our clinical experience using intensity-modulated radiation therapy (IMRT) to improve dose uniformity and treatment efficacy in patients with early-stage breast cancer treated with breast-conserving therapy.Methods and Materials: A total of 281 patients with Stage 0, I, and II breast cancer treated with breast-conserving therapy received whole breast RT after lumpectomy using our static, multileaf collimator (sMLC) IMRT technique. The technical and practical aspects of implementing this technique on a large scale in the clinic were analyzed. The clinical outcome of patients treated with this technique was also reviewed.Results: The median time required for three-dimensional alignment of the tangential fields and dosimetric IMRT planning was 40 and 45 min, respectively. The median number of sMLC segments required per patient to meet the predefined dose-volume constraints was 6 (range 3-12). The median percentage of the treatment given with open fields (no sMLC segments) was 83% (range 38-96%), and the median treatment time was