Morphology and distribution of astrocytes in the molecular layer of the dentate gyrus in NZB/BlNJ, Dreher, and C57BL/6J mice.
Morphology and distribution of astrocytes in the molecular layer of the dentate gyrus in NZB/BlNJ, Dreher, and C57BL/6J mice.
复制标题
NZB/BlNJ、Dreher 和 C57BL/6J 小鼠齿状回分子层星形胶质细胞的形态和分布。
DOI：
10.1002/glia.440100102
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发表时间：
1994
期刊：
影响因子：
6.2
通讯作者：
Nowakowski,RS
中科院分区：
文献类型：
--
作者：
Patrylo,PR;Nowakowski,RS
在NZB/BINJ及其他突变小鼠齿状回分子层发现大量异位颗粒细胞。这些异位神经元可以单独出现，也可以小簇出现。相比之下，C57BL/6J小鼠及其对照组仔鼠齿状分子层中很少见异位颗粒细胞。在这项研究中，我们检测了NZB/BINJ、其他纯合子、其他同卵对照和C57BL/6J小鼠分子层星形胶质细胞的形态、数量和分布，以确定异位颗粒细胞的存在对小鼠的影响。在C57BL/6J小鼠及其对照仔鼠的分子层中，星形胶质细胞呈典型的星形外观，突起向四面八方发散。NZB/BINJ小鼠及其纯合子在异位颗粒细胞缺失区星形胶质细胞的树突与C57BL/6J小鼠及其他对照仔鼠相似。相反，紧邻异位颗粒细胞或异位簇的星形胶质细胞的形态明显非星状。此外，这些星形胶质细胞的体细胞和突起偶尔出现与异位颗粒细胞密切接触。通过定量分析NZB/BINJ与C57BL/6J小鼠以及其他与对照鼠的星形胶质细胞的数量和分布，发现这些参数并未因异位神经元的存在而改变。我们得出结论，异位神经元对胶质细胞的营养作用可以影响星形细胞过程的生长和取向，而不影响胶质细胞的数量。©1994 Wiley‐Liss, Inc。
Numerous ectopic granule cells are found in the molecular layer of the dentate gyrus in NZB/BINJ and dreher mutant mice. These ectopic neurons occur either singly or in small clusters. In contrast, few ectopic granule cells are seen in the dentate molecular layer of C57BL/6J mice and dreher control littermates. In this investigation we have examined the morphology, number, and distribution of molecular layer astrocytes in NZB/BINJ, dreher homozygotes, dreher littermate controls, and C57BL/6J mice to determine the effect of the presence of ectopic granule cells. In the molecular layer of C57BL/6J mice and dreher control littermates, astrocytes have a typical stellate appearance with processes emanating in all directions. The arborization of astrocytes in areas devoid of ectopic granule cells in NZB/BINJ mice and dreher homozygotes was similar to that in C57BL/6J mice and dreher control littermates. In contrast, the morphology of astrocytes in the immediate vicinity of ectopic granule cells or ectopic clusters was distinctly non‐stellate. Furthermore, the somata and processes of these astrocytes occasionally appeared to make intimate contact with the ectopic granule cells. A quantitative analysis of the number and distribution of astrocytes in NZB/BINJ vs C57BL/6J mice and dreher vs. control littermates indicated that these parameters were not altered by the presence of the ectopic neurons. We conclude that the trophic effects of ectopic neurons on glial cells can affect the growth and orientation of astrocytic processes without a concomitant effect on glial cell number. © 1994 Wiley‐Liss, Inc.