Nuclear organization and morphology of cholinergic, putative catecholaminergic and serotonergic neurons in the brain of the rock hyrax, Procavia capensis
Nuclear organization and morphology of cholinergic, putative catecholaminergic and serotonergic neurons in the brain of the rock hyrax, Procavia capensis
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DOI：
10.1016/j.jchemneu.2009.02.005
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发表时间：
2009-09-01
影响因子：
2.8
通讯作者：
Manger, Paul R.
中科院分区：
文献类型：
--
作者：
Gravett, Nadine;Bhagwandin, Adhil;Manger, Paul R.
通过乙酰胆碱酯酶、酪氨酸羟化酶和血清素的免疫组织化学分析，鉴定了岩蹄兔（Procavia capensis）大脑内胆碱能、假定的儿茶酚胺能和血清素能系统的核细分。本研究的目的是通过将岩蹄兔的核细分与已发表的其他哺乳动物的研究进行比较，调查这些系统的核细分互补性中可能存在的差异。岩蹄兔属于蹄兔目，是非洲胎盘目哺乳动物群体的一部分。在很大程度上，这三个系统的核组织与许多其他哺乳动物物种的核组织非常相似。血清素能系统的核组织与所有真兽类哺乳动物中所见的核组织相同。假定的儿茶酚胺能系统的核组织与啮齿动物中所见的核组织非常相似，除了缺乏 C3 核和蓝斑 (A6c) 的紧凑分裂之外。此外，弥漫性蓝斑（A6d）似乎含有很少的酪氨酸羟化酶免疫反应性（TH+）神经元。胆碱能系统显示出许多与啮齿类和灵长类动物相同的特征：然而，存在三个值得注意的差异：（1）在背侧丘脑的前核中观察到胆碱能神经元； (2)在中脑/脑桥界面观察到胆碱能小细胞神经细胞，可能代表中间神经元，形成外侧背核和桥脚被盖核的细分； (3)延髓室周灰质可见大量胆碱能神经细胞。因此，虽然与其他哺乳动物物种有许多相似之处，但岩蹄兔中这些系统的核组织显示出与之前在其他哺乳动物中观察到的特定差异。这些差异从功能和系统发育的角度进行了讨论。 (C) 2009 Elsevier B.V. 保留所有权利。
The nuclear subdivisions of the cholinergic, putative catecholaminergic and serotonergic systems within the brain of the rock hyrax (Procavia capensis) were identified following immunohistochemistry for acetylcholinesterase, tyrosine hydroxylase and serotonin. The aim of the present study was to investigate possible differences in the complement of nuclear subdivisions of these systems by comparing those of the rock hyrax to published studies of other mammals. The rock hyrax belongs to the order Hyracoidea and forms part of the Afroplacentalia mammalian cohort. For the most part, the nuclear organization of these three systems closely resembled that described for many other mammalian species. The nuclear organization of the serotonergic system was identical to that seen in all eutherian mammals. The nuclear organization of the putative catecholaminergic system was very similar to that seen in rodents except for the lack of a C3 nucleus and the compact division of the locus coeruleus (A6c). In addition, the diffuse locus coeruleus (A6d) appeared to contain very few tyrosine hydroxylase immunoreactive (TH+) neurons. The cholinergic system showed many features in common with that seen in both rodents and primates: however, there were three differences of note: (1) cholinergic neurons were observed in the anterior nuclei of the dorsal thalamus; (2) cholinergic parvocellular nerve cells, probably representing interneurons, forming subdivisions of the laterodorsal and pedunculopontine tegmental nuclei were observed at the midbrain/pons interface; and (3) a large number of cholinergic nerve cells in the periventricular grey of the medulla oblongata were observed. Thus, while there are many similarities to other mammalian species, the nuclear organization of these systems in the rock hyrax shows specific differences to what has been observed previously in other mammals. These differences are discussed in both a functional and phylogenetic perspective. (C) 2009 Elsevier B.V. All rights reserved.