Predictive Factors for Postherpetic Neuralgia Using Ordered Logistic Regression Analysis
Predictive Factors for Postherpetic Neuralgia Using Ordered Logistic Regression Analysis
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DOI：
10.1097/ajp.0b013e318243ee01
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发表时间：
2012-10-01
影响因子：
2.9
通讯作者：
Hosokawa, Toyoshi
中科院分区：
文献类型：
--
作者：
Kanbayashi, Yuko;Onishi, Keiko;Hosokawa, Toyoshi
目的：方法：选取2008年1月至2010年6月在我院疼痛门诊就诊的带状疱疹患者73例，分析其发生带状疱疹后遗神经痛（PHN）的预测因素。从临床记录中提取首次访视时存在的变量，用于回归分析PHN发生相关因素。使用以下反应评分：0 = 3个月后无PHN; 1 = 3个月后存在PHN但6个月后不存在; 2 = 6个月后存在PHN。结果：高龄（OR = 2.740，CI = 1.110-6.761; P = 0.0288）和深度疼痛（OR = 2.740，CI = 1.110-6.761; P = 0.0288（OR = 4.244，CI = 1.114-16.163; P = 0.0341）是PHN发生的重要预测因素。糖尿病（OR = 3.075）和疼痛减少洗澡（OR = 3.389）也有较高的OR，虽然他们并不显着。讨论：我们的研究表明，高龄和深度疼痛在首次访问是显着的预测PHN。我们的结果被认为可能有助于建立PHN最佳治疗的循证医学。
Objectives: To identify predictive factors for the occurrence of postherpetic neuralgia (PHN).Methods: The participants were 73 herpes zoster patients who had been treated at the pain clinic of our hospital between January 2008 and June 2010. Variables present at the initial visit were extracted from the clinical records for regression analysis of factors related to the occurrence of PHN. The following scores for response were used: 0 = no PHN after 3 months; 1 = PHN present after 3 months but absent after 6 months; and 2 = PHN present after 6 months. Multivariate ordered logistic regression analysis was performed to identify the predictive factors for PHN.Results: Advanced age [odds ratio (OR) = 2.740, confidence interval (CI) = 1.110-6.761; P = 0.0288] and deep pain (OR = 4.244, CI = 1.114-16.163; P = 0.0341) at the initial visit to our outpatient pain clinic were found to be significant predictive factors for the occurrence of PHN. Diabetes mellitus (OR = 3.075) and pain reduced by bathing (OR = 3.389) also had high OR, although they were not significant.Discussion: Our study indicates that advanced age and deep pain at the initial visit are significant predictors for PHN. Our results are considered likely to contribute to the establishment of evidencebased medicine in the optimal treatment of PHN.