Molecular epidemiology of hepatitis C virus subtype 3a in injecting drug users
Molecular epidemiology of hepatitis C virus subtype 3a in injecting drug users
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DOI：
10.1002/jmv.20692
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发表时间：
2006-10-01
影响因子：
12.7
通讯作者：
Pawlotsky, Jean-Michel
中科院分区：
文献类型：
--
作者：
Morice, Yoann;Cantaloube, Jean-Francois;Pawlotsky, Jean-Michel
丙型肝炎病毒亚型3a （HCV-3a）起源于亚洲，在注射吸毒者和工业化国家的其他患者群体中广泛传播。丙型肝炎病毒亚型3a感染在静脉注射吸毒者中仍然高度流行和频繁传播。本研究的目的是更好地了解全球吸毒者中HCV-3a流行的机制。对来自法国、美国、巴西、阿根廷和澳大利亚的93份hcv -3a感染注射吸毒者的血清进行了研究。非结构5B区域的系统发育分析显示，根据患者的起源大陆，没有特定的聚类。来自南美洲、澳大利亚和加利福尼亚的病毒序列的非排他簇被观察到，但拓扑结构不支持强引导值。结果表明，HCV-3a是通过一种独特的全球流行病从一个共同的起源传播的，这种流行病在吸毒者中迅速蔓延。最近发生了区域性传播，导致HCV-3a在当地注射吸毒人群中出现胚胎遗传多样化。
Hepatitis C virus subtype 3a (HCV-3a) originates from Asia and has spread widely among injecting drug users as well as other patient groups in industrialized countries. HCV subtype 3a infection remains highly prevalent and frequently transmitted in the population of intravenous drug users. The objective of this study was to understand better the mechanisms of the worldwide HCV-3a epidemics in drug users. Ninety-three sera from HCV-3a-infected IDUs from France, the United States, Brazil, Argentina, and Australia were studied. Phylogenetic analyses of the non-structural 5B region showed no specific clustering according to the continent of the patient's origin. Non-exclusive clusters of viral sequences from South America, Australia, and California were observed, but topologies were not supported by strong bootstrap values. The results suggest that HCV-3a has been transmitted from a common origin through a unique worldwide epidemic that rapidly spread among drug users. Regional transmission occurred in the recent past, leading to an embryonic genetic diversification of HCV-3a among local injecting drug user population.