Crosstalk between primary and secondary metabolism: Interconnected fatty acid and polyketide biosynthesis in prokaryotes.
Crosstalk between primary and secondary metabolism: Interconnected fatty acid and polyketide biosynthesis in prokaryotes.
复制标题
初级代谢和次级代谢之间的串扰：原核生物中相互关联的脂肪酸和聚酮化合物生物合成。
DOI：
10.1016/j.bmcl.2023.129377
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发表时间：
2023
影响因子：
2.7
通讯作者：
Bailey,ConstanceB
中科院分区：
文献类型：
--
作者：
West,Anna-KayR;Bailey,ConstanceB
在初级代谢中，脂肪酸合酶 (FAS) 通过丙二酰辅酶 A 的连续克莱森式缩合，然后进行还原处理来生物合成脂肪酸。同样，聚酮合酶 (PKS) 与 FAS 具有相同的生物合成逻辑，其中包括利用相同的前体和辅因子。然而，PKS 生物合成结构多样、复杂的次生代谢物，其中许多与药学相关。本摘要涵盖了脂肪酸和聚酮代谢中初级代谢和次级代谢之间相互关联的生物合成的例子。总而言之，进一步了解聚酮化合物生物合成和脂肪酸生物合成之间的生物合成联系可能会导致改进从聚酮化合物代谢物中发现和生产新药物先导化合物。
In primary metabolism, fatty acid synthases (FASs) biosynthesize fatty acids via sequential Claisen-like condensations of malonyl-CoA followed by reductive processing. Likewise, polyketide synthases (PKSs) share biosynthetic logic with FAS which includes utilizing the same precursors and cofactors. However, PKS biosynthesize structurally diverse, complex secondary metabolites, many of which are pharmaceutically relevant. This digest covers examples of interconnected biosynthesis between primary and secondary metabolism in fatty acid and polyketide metabolism. Taken together, further understanding the biosynthetic linkage between polyketide biosynthesis and fatty acid biosynthesis may lead to improved discovery and production of novel drug leads from polyketide metabolites.