Myocardial Systolic and Diastolic Performance Derived by 2-Dimensional Speckle Tracking Echocardiography in Heart Failure With Normal Left Ventricular Ejection Fraction
Myocardial Systolic and Diastolic Performance Derived by 2-Dimensional Speckle Tracking Echocardiography in Heart Failure With Normal Left Ventricular Ejection Fraction
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DOI：
10.1161/circheartfailure.112.966564
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发表时间：
2012-09-01
影响因子：
9.7
通讯作者：
Haverkamp, Wilhelm
中科院分区：
文献类型：
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作者：
Morris, Daniel A.;Boldt, Leif-Hendrik;Haverkamp, Wilhelm
本研究的目的是通过新的左室心肌指标来评估左室整个心肌的收缩和舒张功能，探讨左室射血分数（HFNEF）正常的心力衰竭患者左室（LV）的心肌收缩和舒张性能。方法与结果：采用二维斑点跟踪超声心动图，以左室各节段纵向、周向和径向的收缩峰值应变和舒张早期峰值应变率平均值分别评价左室收缩和舒张性能。我们研究了HFNEF患者和一个由年龄、性别和左室射血分数相似的无症状左室舒张功能障碍患者组成的对照组。共纳入322例患者（92例为HFNEF， 230例为无症状左室舒张功能障碍）。HFNEF组左室收缩和舒张性能分别为20.13 +/- 6.02%和1.14 +/- 0.27 s(-1)，显著低于无症状左室舒张功能障碍组（25.33 +/- 6.06%和1.37 +/- 0.33 s(-1)）；所有P
Background-The aim of this study was to investigate the myocardial systolic and diastolic performance of the left ventricle (LV) in patients with heart failure with normal LV ejection fraction (HFNEF) through novel LV myocardial indices, which assess the systolic and diastolic function of the whole myocardium of the LV.Methods and Results-LV myocardial systolic and diastolic performance were assessed as the average value of peak systolic strain and peak early-diastolic strain rate, respectively, in longitudinal, circumferential, and radial directions from all LV segments using 2-dimensional speckle-tracking echocardiography. We studied patients with HFNEF and a control group consisting of asymptomatic subjects with LV diastolic dysfunction of similar age, sex, and LV ejection fraction. A total of 322 patients were included (92 with HFNEF and 230 with asymptomatic LV diastolic dysfunction). Myocardial systolic and diastolic LV performance were significantly lower in HFNEF (20.13 +/- 6.02% and 1.14 +/- 0.27 s(-1)) than in patients with asymptomatic LV diastolic dysfunction (25.33 +/- 6.06% and 1.37 +/- 0.33 s(-1), respectively; all P