The association of dietary fat with serum cholesterol in vegetarians: the effect of dietary assessment on the correlation coefficient.
The association of dietary fat with serum cholesterol in vegetarians: the effect of dietary assessment on the correlation coefficient.
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素食者膳食脂肪与血清胆固醇的关联：饮食评估对相关系数的影响。
DOI：
10.1093/oxfordjournals.aje.a115049
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发表时间：
1988
影响因子：
5
通讯作者：
Sacks,FM
中科院分区：
文献类型：
--
作者：
Kushi,LH;Samonds,KW;Lacey,JM;Brown,PT;Bergan,JG;Sacks,FM
在对照饮食研究中确定的膳食脂肪和血清胆固醇之间的生物学关系，在普通人群的横断面研究中通常没有发现。在素食组中，饮食变量与血清胆固醇显著相关。为了探讨膳食评估技术与素食者饮食模式的关系，作者研究了1973年至1974年马萨诸塞州波士顿地区46名以素食为主的成年人的饮食与血清总胆固醇的关系。饮食信息的基础是10天的饮食记录。在调整了年龄、性别和三头肌皮褶的偏相关分析中，血清总胆固醇与膳食胆固醇(r=0.53)和饱和脂肪酸(r=0.50)呈正相关。使用一天的饮食记录将这些相关系数降低到约0.3。对营养素摄入量变异成分的分析表明，与非素食研究组相比，素食者的人内变异较小，人与人之间的变异较高，或两者兼而有之。素食者对膳食脂肪的生物反应与非素食者的Keys方程所预测的相似。因此，饮食记录的多天平均值和相对较小的人内和人间摄入量差异比率有利于检测饮食与血清胆固醇的横截面关联。
The biologic relation between dietary fats and serum cholesterol established in controlled dietary studies usually has not been found in cross-sectional studies of the general population. In vegetarian groups, dietary variables and serum cholesterol have been correlated significantly. To examine the role of technique of dietary assessment versus the dietary pattern of vegetarians, the authors studied the relation of diet with total serum cholesterol in 46 predominantly vegetarian adults in the Boston, Massachusetts, area in 1973–1974. The basis of the dietary information was 10-day diet records. Total serum cholesterol was positively associated with dietary cholesterol (r= 0.53) and saturated fatty acids (r= 0.50) in partial correlation analysis adjusted for age, sex, and triceps skinfold. The use of one-day dietary records lowered these correlation coefficients to about 0.3. Analysis of the components of variation of nutrient intake demonstrated that the vegetarians had a lower within-person variance, a higher between-person variance, or both compared with nonvegetarian study groups. Biologic responsiveness to dietary fat in the vegetarians was similar to that predicted by the Keys equation derived from nonvegetarians. Therefore, multiple-day averaging of dietary records and relatively smaller ratio of within-person to between-person variation in intake favor the detection of cross-sectional associations of diet with serum cholesterol.