Absent gender differences of hippocampal atrophy in amnestic type mild cognitive impairment
Absent gender differences of hippocampal atrophy in amnestic type mild cognitive impairment
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DOI：
10.1016/j.neulet.2008.11.055
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发表时间：
2009-01-30
影响因子：
2.5
通讯作者：
Qian, Yun
中科院分区：
文献类型：
--
作者：
Bai, Feng;Zhang, Zhijun;Qian, Yun
阿尔茨海默病患者的海马表现出与性别相关的渐进性损伤。然而，在遗忘型轻度认知障碍（aMCI）患者的研究中，性别效应在很大程度上被忽视，这些患者被认为是这种疾病的早期阶段。本研究的目的是使用体内神经成像技术来确定是否有任何证据表明aMCI中海马萎缩的性别差异。基于感兴趣区域的磁共振成像方法用于比较aMCI患者（22名男性，17名女性）和正常老年对照（12名男性，11名女性）之间的海马体积。独立于组，雄性海马体积大于雌性体积，右侧海马体积通常小于左侧体积。临床组的海马体积显著减少，但在萎缩程度方面没有观察到性别差异。然而，女性患者的认知功能受损程度高于男性患者，尽管两者在萎缩方面存在明显的等效性。没有性别差异表明，早期神经病理学进展可能与性别无关。然而，数据也表明女性aMCI患者在病程早期对认知障碍的脆弱性增加。皇冠版权所有（C）2008由爱思唯尔爱尔兰有限公司出版。保留所有权利。
Hippocampus displayed progressively gender-associated damage in Alzheimer's disease. However, gender effects have been largely neglected in studies of amnestic type mild cognitive impairment (aMCI) patients who were believed to represent an early stage of this disease. The goal of this study was to use in vivo neuroimaging techniques to determine whether there were any evidences of gender differences in hippocampal atrophy in aMCI. A region of interest-based magnetic resonance imaging approach was used to compare hippocampal volume between aMCI patients (22 male, 17 female) and normal aging controls (12 male, 11 female). Independent of group, male hippocampal volumes were larger than female volumes and right hippocampal volumes were typically smaller than left volumes. Hippocampal volumes were significantly reduced in the clinical group but no gender differences were noted in terms of degree of atrophy present. However, female patients showed more impaired cognitive function than male patients despite this apparent equivalence in atrophy. The absence of a gender difference suggested that early neuropathological progression might be independent of gender. However, the data also suggested female aMCI patients had an increased vulnerability to cognitive impairment earlier in the illness course. Crown Copyright (C) 2008 Published by Elsevier Ireland Ltd. All rights reserved.