Therapeutic Implications of Mesenchymal Stromal Cells and Their Extracellular Vesicles in Autoimmune Diseases: From Biology to Clinical Applications.
Therapeutic Implications of Mesenchymal Stromal Cells and Their Extracellular Vesicles in Autoimmune Diseases: From Biology to Clinical Applications.
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间充质基质细胞及其细胞外囊泡在自身免疫性疾病中的治疗意义：从生物学到临床应用。
DOI：
10.3390/ijms221810132
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发表时间：
2021-09-20
影响因子：
5.6
通讯作者：
Pontikoglou CG
中科院分区：
文献类型：
--
作者：
Matheakakis A;Batsali A;Papadaki HA;Pontikoglou CG
间充质基质细胞 (MSC) 是血管周围多能干细胞，最初在骨髓 (BM) 基质中发现，随后在几乎所有血管化组织中发现。由于其分化成各种中胚层谱系的能力、营养特性、归巢能力和免疫调节功能，间充质干细胞已成为组织修复和自身免疫性疾病治疗中有吸引力的候选者。越来越多的证据表明，间充质干细胞的有益作用可能主要是通过许多具有旁分泌作用的可溶性因子和细胞外囊泡（EV）介导的。 EV 是一种膜包被的囊泡，人们越来越认识到它们通过其向受体细胞携带和递送其货物（包括蛋白质、核酸和脂质）的能力，在细胞间通讯中发挥着关键作用。 MSC-EV 概括了它们起源的细胞的功能，包括免疫调节作用，但似乎与基于细胞的疗法的局限性和担忧无关，从而成为免疫介导疾病的一种有吸引力的替代治疗选择。在本综述中，将概述 MSC 的生物学，并概述其免疫调节功能。此外，还将总结目前关于 MSC-EV 的特征及其免疫调节潜力的知识。最后，将讨论 MSC 和 MSC-EV 在自身免疫性疾病中的治疗应用。
Mesenchymal stromal cells (MSCs) are perivascular multipotent stem cells originally identified in the bone marrow (BM) stroma and subsequently in virtually all vascularized tissues. Because of their ability to differentiate into various mesodermal lineages, their trophic properties, homing capacity, and immunomodulatory functions, MSCs have emerged as attractive candidates in tissue repair and treatment of autoimmune disorders. Accumulating evidence suggests that the beneficial effects of MSCs may be primarily mediated via a number of paracrine-acting soluble factors and extracellular vesicles (EVs). EVs are membrane-coated vesicles that are increasingly being acknowledged as playing a key role in intercellular communication via their capacity to carry and deliver their cargo, consisting of proteins, nucleic acids, and lipids to recipient cells. MSC-EVs recapitulate the functions of the cells they originate, including immunoregulatory effects but do not seem to be associated with the limitations and concerns of cell-based therapies, thereby emerging as an appealing alternative therapeutic option in immune-mediated disorders. In the present review, the biology of MSCs will be outlined and an overview of their immunomodulatory functions will be provided. In addition, current knowledge on the features of MSC-EVs and their immunoregulatory potential will be summarized. Finally, therapeutic applications of MSCs and MSC-EVs in autoimmune disorders will be discussed.
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影响因子：
7.5
作者：
Batsali AK;Pontikoglou C;Koutroulakis D;Pavlaki KI;Damianaki A;Mavroudi I;Alpantaki K;Kouvidi E;Kontakis G;Papadaki HA
通讯作者：
Papadaki HA
影响因子：
3.7
作者：
Bruno S;Grange C;Collino F;Deregibus MC;Cantaluppi V;Biancone L;Tetta C;Camussi G
通讯作者：
Camussi G
影响因子：
4.8
作者：
Casiraghi, Federica;Remuzzi, Giuseppe;Perico, Norberto
通讯作者：
Perico, Norberto
影响因子：
7.3
作者：
Adamo, Annalisa;Brandi, Jessica;Krampera, Mauro
通讯作者：
Krampera, Mauro
影响因子：
3.3
作者：
Budoni, Manuela;Fierabracci, Alessandra;Muraca, Maurizio
通讯作者：
Muraca, Maurizio