Metabolism of C-14-labelled sucrose esters of stearic acid in rats
Metabolism of C-14-labelled sucrose esters of stearic acid in rats
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DOI：
10.1016/s0278-6915(97)00012-4
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发表时间：
1997-06-01
影响因子：
4.3
通讯作者：
Shigeoka, T
中科院分区：
文献类型：
--
作者：
Noker, PE;Lin, TH;Shigeoka, T
通过经口管饲法（250 mg/kg）对大鼠给药含有在四个、六个或八个位置用硬脂酸酯化的蔗糖的化合物。对于每种化合物，大鼠通过粪便排泄超过95%的剂量。放射性的吸收和代谢程度与酯化程度呈负相关。对于给予脂肪酸部分标记蔗糖酯的大鼠，四酯化化合物的放射性吸收程度最高（剂量的5.9%）。在该衍生物给药后120 h，除胃肠道组织外，在脂肪中发现最高放射性浓度（183 μ g当量/g组织），淋巴结（117微克当量/克组织）和肝脏（88 μ g当量/g组织）;血液（3.9 μ g当量/g组织）和收集的淋巴液（剂量的5.0-7.6%）中出现明显的放射性。对于给予蔗糖部分标记的酯的大鼠，吸收的放射性量低于给予脂肪酸部分标记的相应蔗糖衍生物后的放射性量;给予四酯化化合物后吸收的放射性最大（3.0%）。在从这些大鼠采集的组织样本中发现相对较少的放射性。这些结果与蔗糖酯在肠道吸收前的有限水解一致，推测为蔗糖和脂肪酸。(C)1997 Elsevier Science Ltd.
Rats were dosed by oral gavage (250 mg/kg) with compounds containing sucrose esterified in four, six or eight positions with stearic acid. For each compound, rats excreted greater than 95% of the dose in the faeces. The extent of absorption and metabolism of radioactivity was inversely related to the degree of esterification. For rats dosed with sucrose esters labelled in the fatty acid moieties, the degree of absorption of radioactivity was highest for the tetraesterified compound (5.9% of the dose). At 120 hr after dosing with this derivative, the highest concentrations of radioactivity, aside from tissues of the gastrointestinal tract, were found in fat (183 mu g-equivalents/g tissue), lymph nodes (117 mu g-equivalents/g tissue) and the liver (88 mu g-equivalents/g tissue); appreciable radioactivity appeared in the blood (3.9 mu g-equivalents/g tissue) and collected lymph (5.0-7.6% of the dose). For rats dosed with esters labelled in the sucrose moiety, the amounts of radioactivity absorbed were lower than after dosing with the corresponding sucrose derivatives labelled in the fatty acid moieties; the absorbed radioactivity was greatest following administration of the tetraesterified compound (3.0%). Relatively little radioactivity was found in tissue samples collected from these rats. These results are consistent with limited hydrolysis of the sucrose esters, presumably to sucrose and fatty acids, prior to intestinal absorption. (C) 1997 Elsevier Science Ltd.