Anthracene and Anthraquinone Derivatives from the Stem Bark of Juglans mandshuricaMaxim.
Anthracene and Anthraquinone Derivatives from the Stem Bark of Juglans mandshuricaMaxim.
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DOI：
10.1002/hlca.201000462
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发表时间：
2011-08
影响因子：
1.8
通讯作者：
Hua Lin;Yu-wei Zhang;Li-hua Zheng;X. Meng;Y. Bao;Yin Wu;Chun-lei Yu;Yan-xin Huang;Yuxin Li-
中科院分区：
文献类型：
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作者：
Hua Lin;Yu-wei Zhang;Li-hua Zheng;X. Meng;Y. Bao;Yin Wu;Chun-lei Yu;Yan-xin Huang;Yuxin Li-
东北师范大学遗传与细胞学研究所，长春市人民大街5268号，邮编：130024。从胡桃楸（Juglans mandshurica）树皮中分离得到一个新的蒽衍生物胡桃蒽甙A（1），两个新的蒽醌化合物胡桃蒽醌酮A（2）和胡桃蒽醌B（3），沿着一个新的天然蒽醌化合物9，10-二氢-4，8-二羟基-9，10-二氧蒽-2-羧酸（4）。通过详细的光谱分析和与相关化合物的NMR数据的比较，确定了它们的结构。化合物1在1，1-二苯基-2-苦基肼（DPPH）和2，2 '-连氮双（3-乙基苯并噻唑啉-6-磺酸）（ABTS）自由基清除实验中均表现出较好的抗氧化活性，而化合物4在体外对HepG 2、SGC 7901、HCT-8和A549细胞株表现出较强的细胞毒性。
) Institute of Genetics and Cytology, Northeast Normal University, Renmin Street 5268,ChangChun 130024, P. R. ChinaOne new anthracene derivative, juglanthracenoside A (1), two new anthraquinones, juglanthraqui-none A (2) and juglanthraquinone B (3), along with a new naturally occurring anthraquinone, 9,10-dihydro-4,8-dihydroxy-9,10-dioxoanthracene-2-carboxylic acid (4), have been isolated from the stembark of Juglans mandshurica. Their structures were established by detailed spectroscopic analysis andcomparison of the NMR data with those of related compounds. Compound 1 displayed noticeableantioxidantactivityinboth1,1-diphenyl-2-picrylhydrazyl(DPPH)and2,2’-azinobis(3-ethylbenzothiazo-line-6-sulfonic acid) (ABTS) free radical-scavenging assays, while compound 4 showed strongcytotoxicity against HepG2, SGC7901, HCT-8, and A549 cell lines in vitro.