On the stimulation of new bone-formation with parathyroid extract and irradiated ergosterol
On the stimulation of new bone-formation with parathyroid extract and irradiated ergosterol
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DOI：
10.1210/endo-16-5-547
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发表时间：
1932-09-01
期刊：
影响因子：
4.8
通讯作者：
Selye, H
中科院分区：
文献类型：
--
作者：
Selye, H
小剂量甲状旁腺激素导致大鼠成骨细胞增殖。这些成骨细胞诱导新骨形成。这样处理的动物的骨变得如此致密，以至于干骺端的松质骨看起来像致密的骨组织。这些变化模拟了人类大理石骨疾病（Morbus Albers-Schonberg）的变化。尽管已知大剂量的甲状旁腺激素会产生纤维性骨炎和骨吸收，但这些实验表明小剂量的甲状旁腺激素具有相反的效果，并导致骨密度增加。长期服用辐照麦角固醇也会导致骨密度增加，但这些骨的组织学特征与甲状旁腺激素产生的骨不同。
Small doses of parathyroid hormone lead to osteoblast proliferation in the rat. These osteoblasts induce new bone formation. The bone of the animal so treated becomes so dense that the spongiosa of the metaphysis looks like compact bone tissue. The changes simulate those seen in humans in marble-bone disease (Morbus Albers-Schonberg). Whereas large doses of parathyroid hormone are known to produce osteitis fibrosa and bone resorption, these experiments show that small doses have the opposite effect and lead to increased bone density. Prolonged administration of irradiated ergosterol leads also to Increased bone density, but the histological features of these bones are different from those produced by parathyroid hormone.