THE EXPRESSION OF PARATHYROID HORMONE-RELATED PROTEIN IN HUMAN BREAST-CANCER WITH SKELETAL METASTASES
THE EXPRESSION OF PARATHYROID HORMONE-RELATED PROTEIN IN HUMAN BREAST-CANCER WITH SKELETAL METASTASES
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DOI：
10.1007/bf02032890
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发表时间：
1994-01-01
期刊：
影响因子：
--
通讯作者：
SAITOH, Y
中科院分区：
文献类型：
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作者：
KOHNO, N;KITAZAWA, S;SAITOH, Y
应用抗人甲状旁腺激素相关蛋白（PTHrP）单克隆抗体（4B3）研究乳腺癌中PTHrP表达与骨骼转移的关系。在1980年至1985年间手术获得的28例乳腺癌的福尔马林固定石蜡包埋组织切片中，研究了PTHrP的免疫组织化学定位。在28例患者中，12例发生骨骼转移，8例发生肺转移，另外8例在本研究时存活且无疾病。28例肿瘤中有16例（57%）显示4B3免疫反应阳性，其中骨骼转移患者PTHrP阳性比例为83%，肺转移患者为38%，无复发患者为38%。因此，发生骨骼转移的患者PTHrP阳性比例明显高于其他两组（P < 0.05）。此外，阳性染色水平与雌激素和孕激素受体阳性呈极显著相关（P < 0.01）。这些结果与PTHrP可能是转移瘤侵蚀骨骼和在骨骼部位生长所必需的假设一致，其表达可能与某些激素有关。
The relationship between the expression of parathyroid hormone-related protein (PTHrP) by breast cancer and skeletal metastases, was investigated using a monoclonal antibody against human PTHrP (4B3). The immunohistochemical localization of PTHrP was studied in sections of formalin-fixed, paraffin-embeded tissues from 28 breast cancers obtained surgically between 1980 and 1985. Of the 28 patients, 12 developed skeletal metastases, 8 developed lung metastases, and the other 8 were alive and disease-free at the time of this study. Sixteen of the 28 (57%) tumors showed positive immunoreactivity to 4B3, the PTHrP positive ratio being 83% in the patients who developed skeletal metastases, 38% in those who developed lung metastases, and 38% in those without recurrence, respectively. Thus, a significantly higher proportion of the patients who developed skeletal metastases were positive for PTHrP than the other two groups (P < 0.05). Furthermore, the level of positive staining was strongly related to positivity for estrogen and progesterone receptors (P < 0.01). These results are consistent with the hypothesis that PTHrP might be necessary for metastases to erode bone and grow in skeletal sites, and its expression could be related to certain hormones.