Patients with stable uncomplicated cirrhosis have normal neutrophil function
Patients with stable uncomplicated cirrhosis have normal neutrophil function
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DOI：
10.1046/j.1440-1746.2000.02232.x
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发表时间：
2000-11-01
影响因子：
4.1
通讯作者：
Kirsch, RE
中科院分区：
文献类型：
--
作者：
Kirsch, R;Woodburne, VE;Kirsch, RE
背景：据报道，肝硬化患者的中性粒细胞功能异常。为了评估肝细胞功能障碍和门体血液分流对这些异常的相对影响，对 18 名肝硬化和门静脉高压患者的中性粒细胞功能进行了研究。研究人员还对 9 名因门静脉血栓形成导致的肝外门静脉高压 (EPH) 患者进行了研究，这些患者没有肝病的临床、生化或组织学证据。方法：测量了这些患者以及年龄和性别对照患者的超氧化物生成、吞噬作用、脱颗粒、白三烯 B4 释放、念珠菌活性以及细胞表面粘附标记 CD 11b/CD18 的定量和定性表达。肝硬化患者中，N-甲酰基-甲硫氨酰-亮氨酰-苯丙氨酸-中性粒细胞中 MAC1 成分 CD 的表达出现小幅但具有统计学意义的下降（P = 0.04）。对于所测试的中性粒细胞功能的任何其他参数，两个患者组和对照组之间均未发现显着差异。 结论：根据其他地方发表的数据，这些结果是意外的发现，表明肝硬化患者的中性粒细胞功能受损。研究表明，稳定、无并发症的肝硬化患者和 EPH 患者的中性粒细胞功能正常。 (C) 2000 布莱克韦尔科学亚洲有限公司
Background: Neutrophil function has been reported to be abnormal in patients with cirrhosis. In order to evaluate the relative contribution of hepatocellular dysfunction and portalsystemic shunting of blood to these abnormalities, neutrophil function was studied in 18 patients with cirrhosis and portal hypertension. Nine patients, with extrahepatic portal hypertension (EPH) caused by portal vein thrombosis, who had no clinical, biochemical or histologic evidence of liver disease were also studied.Methods: Superoxide generation, phagocytosis, degranulation, leuko triene B4 release, candidacidal activity and quantitative and qualitative expression of the cell surface adhesive marker CD 11b/CD18 were measured in these patients as well as in age- and gender-marched controls.Results: Patients with cirrhosis were,found to have a small but statistically significant decrease in the expression of the CD is component of MAC1 in N-formyl-methionyl-leucyl-phenylalanine-neutrophils (P = 0.04). No significant differences were found between either of the two patient groups and the control group for any of the other parameters of neutrophil function tested.Conclusions: These were unexpected findings in the light of data published elsewhere, which indicate impaired neutrophil function in patients with cirrhosis. The study suggests that patients with stable, uncomplicated cirrhosis and patients with EPH have normal neutrophil function. (C) 2000 Blackwell Science Asia Pty Ltd.