The natural history of IgE-mediated cow's milk allergy
The natural history of IgE-mediated cow's milk allergy
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DOI：
10.1016/j.jaci.2007.08.023
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发表时间：
2007-11-01
影响因子：
14.2
通讯作者：
Wood, Robert A.
中科院分区：
文献类型：
--
作者：
Skripak, Justin M.;Matsui, Elizabeth C.;Wood, Robert A.
背景：牛奶过敏 (CMA) 是婴幼儿中最常见的食物过敏，影响总人口的 2% 至 3%。大多数研究表明，对牛奶产生耐受性的预后良好，其中大多数在 3 岁时不再过敏。 目的： 确定 CMA 的自然病程，并确定在大量转诊 CMA 儿童中最能预测结果的因素。 方法： 收集 807 名 IgE 介导的 CMA 患者的临床病史、测试结果和最终结果。患者在通过挑战或在过去 12 个月内没有出现反应并且具有牛奶 IgE (cm-IgE) 水平后被认为具有耐受性
Background: Cow's milk allergy (CMA) is the most common food allergy in infants and young children, affecting 2 % to 3 % of the general population. Most studies have shown the prognosis of developing tolerance to cow's milk to be good, with most outgrowing their allergy by age 3 years.Objective: To define the natural course of CMA and identify the factors that best predict outcome in a large referral population of children with CMA.Methods: Clinical history, test results, and final outcome were collected on 807 patients with IgE-mediated CMA. Patients were considered tolerant after they passed a challenge or experienced no reactions in the past 12 months and had a cow's milk IgE (cm-IgE) level