The Dishevelled Protein Family: Still Rather a Mystery After Over 20 Years of Molecular Studies.
The Dishevelled Protein Family: Still Rather a Mystery After Over 20 Years of Molecular Studies.
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DOI：
10.1016/bs.ctdb.2015.11.027
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发表时间：
2016
影响因子：
--
通讯作者：
Mlodzik M
中科院分区：
文献类型：
--
作者：
Mlodzik M
Dishevelled（Dsh）是Wnt信号通路的关键组成部分，也可能具有其他功能要求。Dsh似乎是一个关键因素来解释Wnt信号来自通过Wnt受体家族，卷曲蛋白，从质膜和路由到正确的细胞内途径。然而，如何调节Dsh中继信号流与相同的Wnt受体家族的相互作用后，特定的和不同的细胞反应仍然知之甚少。
Dishevelled (Dsh) is a key component of Wnt-signaling pathways and possibly also has other functional requirements. Dsh appears to be a key factor to interpret Wnt signals coming via the Wnt-receptor family, the Frizzled proteins, from the plasma membrane and route them into the correct intracellular pathways. However, how Dsh is regulated to relay signal flow to specific and distinct cellular responses upon interaction with the same Wnt-receptor family remains very poorly understood.