Late budding domains and host proteins in enveloped virus release
Late budding domains and host proteins in enveloped virus release
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DOI：
10.1016/j.virol.2005.09.044
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发表时间：
2006-01-05
期刊：
影响因子：
3.7
通讯作者：
Bieniasz, PD
中科院分区：
文献类型：
--
作者：
Bieniasz, PD
细胞外包膜病毒颗粒发生的必要步骤是形成外病毒体膜。通常，病毒体膜来源于宿主细胞膜，并且这提出了一个问题，因为病毒体与宿主膜的分离不是微不足道的或自发的步骤。事实上，病毒已经进化出许多不同复杂性的策略来处理这个问题。例如，疱疹病毒和痘病毒已经发展出连续的膜包裹和融合活动，最终产生具有一个或多个脂质双层的细胞外病毒颗粒。对于简单的病毒来说，它们通过在宿主细胞膜的双层中出芽来获得包膜，新生病毒体膜从宿主细胞膜中分裂出来需要不同的方法。这些病毒中的至少一些已经通过模拟和/或选择细胞在核内体内形成含细胞质的囊泡期间通常使用的因子来解决该问题。负责这些病毒体和囊泡出芽事件的病毒和细胞编码的活动目前是一个非常感兴趣的领域，并且正在发现两个过程中的许多有趣的相似之处和差异。
A necessary step in the genesis of an extracellular enveloped virus particle is the formation of an outer virion membrane. Often, virion membrane is derived from host cell membranes, and this presents a problem because separation of virion from host membrane is not a trivial or spontaneous step. Indeed, viruses have evolved a number of strategies of varying complexity to deal with this issue. Herpes-and poxviruses for instance, have developed sequential membrane wrapping and fusion activities that ultimately give rise to extracellular virus particles with one or more lipid bilayers. For simpler viruses that acquire their envelopes by budding through a single host membrane bilayer, the fission of the nascent virion membrane from that of the host cell requires a different approach. At least some of these viruses have solved the problem by mimicking and/or coopting factors that cells usually employ during the formation of cytoplasm-containing vesicles within endosomes. The virus and cell encoded activities that are responsible for these virion and vesicle budding events are currently an area of intense interest and a number of interesting parallels and differences in the two processes are being uncovered.