Liver regeneration microenvironment of hepatocellular carcinoma for prevention and therapy.
Liver regeneration microenvironment of hepatocellular carcinoma for prevention and therapy.
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DOI：
10.18632/oncotarget.12101
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发表时间：
2017-01-03
期刊：
影响因子：
--
通讯作者：
Zhang L
中科院分区：
文献类型：
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作者：
Li H;Zhang L
肝癌防治的研究主要集中在肝癌细胞本身。目前，肝癌不再仅仅被视为基因改变细胞的集合，而是具有可塑性基质、基质和脉管系统的异常器官。改善肝脏微环境，通过影响免疫功能、炎症和血管系统来促进肝脏再生和修复，可以调节正常肝脏再生和修复与异常肝脏再生之间的动态失衡，从而改善肝脏再生微环境，从而预防和治疗肝癌。这篇综述讨论了肝脏再生微环境的基本理论，包括免疫、炎症和脉管系统的最新发现。肝细胞癌（HCC）微环境中分子靶点的潜在设计受到关注。为了改善肝癌的肝再生微环境，研究人员广泛利用增强免疫力、抗炎和血管生态位等手段，本文对此进行了详细讨论。此外，作者总结了血管生态位的最新促纤维化转变特征，并回顾了肝病的潜在细胞疗法。
Research on liver cancer prevention and treatment has mainly focused on the liver cancer cells themselves. Currently, liver cancers are no longer viewed as only collections of genetically altered cells but as aberrant organs with a plastic stroma, matrix, and vasculature. Improving the microenvironment of the liver to promote liver regeneration and repair by affecting immune function, inflammation and vasculature can regulate the dynamic imbalance between normal liver regeneration and repair and abnormal liver regeneration, thus improving the microenvironment of liver regeneration for the prevention and treatment of liver cancer. This review addresses the basic theory of the liver regeneration microenvironment, including the latest findings on immunity, inflammation and vasculature. Attention is given to the potential design of molecular targets in the microenvironment of hepatocellular carcinoma (HCC). In an effort to improve the liver regeneration microenvironment of HCC, researchers have extensively utilized the enhancement of immunity, anti-inflammation and the vasculature niche, which are discussed in detail in this review. In addition, the authors summarize the latest pro-fibrotic transition characteristics of the vascular niche and review potential cell therapies for liver disease.