Prevalence and clinical outcome of hepatitis C infection in children who underwent cardiac surgery before the implementation of blood-donor screening.
Prevalence and clinical outcome of hepatitis C infection in children who underwent cardiac surgery before the implementation of blood-donor screening.
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实施献血者筛查前接受心脏手术的儿童丙型肝炎感染的患病率和临床结果。
DOI：
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发表时间：
1999
期刊：
影响因子：
--
通讯作者：
J. Hess
中科院分区：
文献类型：
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作者：
M. Vogt;T. Lang;G. Frösner;C. Klingler;A. Sendl;A. Zeller;B. Wiebecke;B. Langer;H. Meisner;J. Hess
背景与方法关于儿童丙型肝炎感染的患病率和临床转归的资料很少。我们研究了1991年之前在德国慕尼黑接受心脏手术的458名儿童，当时德国引入了丙型肝炎献血者筛查。他们第一次手术的平均年龄为2.8岁；这些孩子在心脏手术前后没有接受过输血，他们的母亲也没有丙型肝炎病毒抗体(抗-HCV)。我们将这些患者与458名年龄和性别匹配的对照组进行了比较。结果458例心脏手术患者中有67例(14.6%)抗-丙型肝炎病毒阳性，而对照组有3例(0.7%)抗-丙型肝炎病毒阳性(P<；0.001)。在第一次手术后平均19.8年的时间里，67名抗-HCV阳性的患者中有37名(55%)在他们的血液中检测到了丙型肝炎病毒RNA。另有30例患者感染已清除，三种聚合酶链式反应和聚合酶链式反应检测结果均为阴性。
Background and Methods There are few data on the prevalence and clinical outcome of hepatitis C infection in children. We studied 458 children who underwent cardiac surgery in Munich, Germany, before 1991, when blood-donor screening for hepatitis C was introduced in Germany. Their mean age at first operation was 2.8 years; none of the children had received blood transfusions before or after cardiac surgery, and none of their mothers had antibodies to hepatitis C virus (anti-HCV). We compared these patients with 458 control subjects matched for age and sex. Results Sixty-seven (14.6 percent) of the 458 patients who had undergone cardiac surgery had anti-HCV, as compared with 3 (0.7 percent) of the control subjects (P<0.001). At a mean interval of 19.8 years after the first operation, 37 (55 percent) of the 67 patients who were positive for anti-HCV had detectable HCV RNA in their blood. The infection had cleared in the other 30 patients, as evidenced by negative results on three polymerase-chain-reaction a...
接受体外膜肺氧合的儿童丙型肝炎感染。
影响因子：
2.4
作者：
Nelson,SP;Jonas,MM
通讯作者：
Jonas,MM
影响因子：
158.5
作者：
McHutchison, JG;Gordon, SC;Albrecht, JK
通讯作者：
Albrecht, JK
与静脉注射免疫球蛋白相关的丙型肝炎病毒感染的临床和病毒学特征。
影响因子：
8
作者：
Jonas,MM;Baron,MJ;Bresee,JS;Schneider,LC
通讯作者：
Schneider,LC