Passive smoking at home and cancer risk: a population-based prospective study in Japanese nonsmoking women
Passive smoking at home and cancer risk: a population-based prospective study in Japanese nonsmoking women
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DOI：
10.1023/a:1012273806199
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发表时间：
2001-11-01
影响因子：
2.3
通讯作者：
Hisamichi, S
中科院分区：
文献类型：
--
作者：
Nishino, Y;Tsubono, Y;Hisamichi, S
目的：在一项基于人群的前瞻性研究中探讨家庭被动吸烟与各种癌症发病率之间的关系。方法：研究对象为居住在宫城县三个市的 9675 名 40 岁以上终身不吸烟的日本女性，并于 1984 年完成了一份自我管理问卷。在 9 年的随访期间，通过与基于人群的癌症登记处的记录链接，发现了 426 种癌症。使用Cox比例风险模型对数据进行分析。结果：与丈夫不吸烟的女性相比，丈夫吸烟的女性患吸烟相关癌症和肺癌的年龄调整相对风险（RR）和95%置信区间（CI）分别为1.7（0.94-2.9，p = 0.079）和1.9（0.81-4.4，p = 0.14）。相比之下，乳腺癌存在显着的负相关； RR (95% CI) 为 0.58 (0.34-0.99, p = 0.047)。对混杂因素进行多变量调整后，与吸烟相关的癌症和乳腺癌的风险基本没有变化。结论：这些结果表明，被动吸烟可能会影响肺癌以外的其他癌症的风险。
Objectives: To investigate the relationship between passive smoking at home and the incidence of various cancers in a population-based prospective study.Methods: The subjects were 9675 Japanese lifelong nonsmoking women aged over 40 years who lived in three municipalities of Miyagi Prefecture, and completed a self-administration questionnaire in 1984. During 9 years of follow-up, 426 cancers were identified by record linkage to the population-based cancer registry. The data were analyzed using the Cox proportional hazards model.Results: The age-adjusted relative risks (RR) and 95% confidence intervals (CI) of smoking-related cancers and lung cancer for women who had smoking husbands, compared with women whose husbands did not smoke, were 1.7 (0.94-2.9, p = 0.079) and 1.9 (0.81-4.4, p = 0.14), respectively. In contrast, a significant inverse association was observed for breast cancer; the RR (95% CI) was 0.58 (0.34-0.99, p = 0.047). After multivariate adjustment for confounding factors, the risks of smoking-related cancers and breast cancer were materially unchanged.Conclusions: These results show that passive smoking may affect the risk of cancers other than lung cancer.