Assessment of predictions submitted for the CASP7 function prediction category
Assessment of predictions submitted for the CASP7 function prediction category
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DOI：
10.1002/prot.21651
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发表时间：
2007-01-01
影响因子：
2.9
通讯作者：
Valencia, Alfonso
中科院分区：
文献类型：
--
作者：
Lopez, Gonzalo;Rojas, Ana;Valencia, Alfonso
在这里，我们提出了一个完整的概述蛋白质结构预测的关键评估（CASP7）功能预测类别。预测提交基因本体分子功能术语，酶委员会编号，和配体结合位点残基。前两个类别很难评估，因为在实验后几乎没有新的功能信息。在实验之前，大多数已知的基因本体论术语和所有酶委员会的编号都是先验的，因此对这两个类别的预测不是盲目的。尽管如此，对于基因本体论术语，我们能够证明一些群体比其他群体做出更好的预测。在结合残基类别中，预测者事先不知道哪些配体被结合，因此盲法评估是可能的，但在这一类别中的预测令人不安地少。在CASP 6和7之后，组织更有效的盲法功能预测类别的需求是显而易见的，即使这意味着将结合位点预测作为唯一可以真正按照CASP精神进行评估的类别。
Here we present a full overview of the Critical Assessment of Protein Structure Prediction (CASP7) function prediction category. Predictions were submitted for Gene Ontology molecular function terms, Enzyme Commission numbers, and ligand binding site residues. The first two categories were difficult to assess because very little new functional information becomes available after the experiment. The majority of the known Gene Ontology terms and all the Enzyme Commission numbers were available a priori to predictors before the experiment, so prediction for these two categories was not blind. Nevertheless, for Gene Ontology terms we were able to demonstrate that some groups made better predictions than others. In the binding residue category, the predictors did not know in advance which ligands were bound and therefore blind evaluation was possible, but there were disappointingly few predictions in this category. After CASP 6 and 7 the need to organize a more effective blind function prediction category is obvious, even if it means focusing on binding site prediction as the only category that can be truly assessed in the CASP spirit.