Linking temperamental fearfulness and anxiety symptoms: A behavior-genetic perspective
Linking temperamental fearfulness and anxiety symptoms: A behavior-genetic perspective
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DOI：
10.1016/s0006-3223(00)01003-9
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发表时间：
2000-12-15
影响因子：
10.6
通讯作者：
Lemery, KS
中科院分区：
文献类型：
--
作者：
Goldsmith, HH;Lemery, KS
历史上，对情绪和焦虑症的研究一直没有充分参考越来越多关于典型情绪发展和气质本质的工作。回顾几项研究的数据，我们认为经验、生物和一般因素为婴儿期和幼儿期恐惧和焦虑的典型发展变化提供了因果输入。纵向行为方法、心理生理学测量和行为遗传框架用于解决这些问题。双胞胎研究的结果表明，遗传对气质恐惧的不同方面以及儿童焦虑症状有中等强度的影响。然后，我们从定量的一般角度考虑正常范围的气质和明显的焦虑症状之间的区别。抑制行为的生物相关性（皮质醇、不对称额叶脑电图激活心脏反应性）被认为是与 I 相关的焦虑内表型。在非遗传分析中，我们报告了根据早期气质和早期基础皮质醇测量对幼儿园期间内化问题的预测。我们的综述强调了行为指标与各种假定的内表型之间的联系以及正常范围气质与焦虑症之间的模糊界限。（C）2000 年生物精神病学协会。
Research on mood and anxiety disorders has historically proceeded without sufficient reference to the growing body of work on the nature of typical emotional development and temperament. Reviewing data from several studies, we consider experiential, biological, and generic factors as providing causal input to typical developmental variation in fearfulness and anxiety during infancy and early childhood. Longitudinal behavioral methods, psychophysiologic measures, and a behavior-genetic framework are used to approach these issues. Results from twin studies implicate moderately strong genetic influences on different facets of temperamental fearfulness, as well as childhood anxiety symptoms. Then, we consider the dis tinction between normal range temperament and overt anxiety symptoms from a quantitative generic perspective. Biological correlates (cortisol, asymmetric frontal EEG activation cardiac reactivity) of inhibited behavior are considered as I-elated endophenotypes for anxiety. In a nongenetic analysis, we report the prediction of internalizing problems during kindergarten from earlier temperament and earlier basal cortisol measures. Our review highlights connections between behavioral indicators and various putative endophenotypes and the fuzzy boundary between normal-range temperament and anxiety disorders.. (C) 2000 Society of Biological Psychiatry.