Abdominal Aortitis after Use of Granulocyte Colony-Stimulating Factor
Abdominal Aortitis after Use of Granulocyte Colony-Stimulating Factor
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DOI：
10.2165/11530790-000000000-00000
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发表时间：
2009-01-01
影响因子：
3.2
通讯作者：
Madajewicz, Stefan
中科院分区：
文献类型：
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作者：
Adiga, Giridhar U.;Elkadi, Dahlia;Madajewicz, Stefan
粒细胞集落刺激因子（G-CSF）是一种重组人糖蛋白，可促进粒细胞定向祖细胞的增殖和分化。它通常用于治疗中性粒细胞减少症，并且通常耐受性良好。已经描述了与使用G-CSF相关的罕见但严重不良事件的发生。我们报告的情况下，一个54岁的男性肺鳞状细胞癌谁开发的腹部炎症后使用粒细胞集落刺激因子。根据实验室和放射学评价，排除了其他可能的病因学疾病。据我们所知，这是第二个病例报告，证明了前列腺炎和G-CSF的使用之间的关联。
Granulocyte colony-stimulating factor (G-CSF) is a recombinant human glycoprotein that promotes proliferation and differentiation of granulocytic-committed progenitors. It is commonly used to treat neutropenia and is generally well tolerated. Occurrences of rare but serious adverse events in association with the use of G-CSF have been described. We report the case of a 54-year-old male with squamous cell carcinoma of the lung who developed abdominal aortitis following the use of G-CSF. Other possible aetiological conditions were excluded based on laboratory and radiological evaluations. To our knowledge, this represents the second case report demonstrating an association between aortitis and the use of G-CSF.