COMPARISON OF 2 FORMS OF LONG-TERM POTENTIATION IN SINGLE HIPPOCAMPAL-NEURONS
COMPARISON OF 2 FORMS OF LONG-TERM POTENTIATION IN SINGLE HIPPOCAMPAL-NEURONS
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DOI：
10.1126/science.2114039
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发表时间：
1990-06-29
期刊：
影响因子：
56.9
通讯作者：
NICOLL, RA
中科院分区：
文献类型：
--
作者：
ZALUTSKY, RA;NICOLL, RA
在无脊椎动物的神经系统中，突触效能的某些长期增强是由于突触前细胞的变化。在脊椎动物的神经系统中，突触强度的长期变化是海马CA 1区的长时程增强（LTP）。这个过程是在突触后启动的，但持续变化的部位尚未得到解决。单个CA 3海马锥体细胞接受来自联合连合纤维和齿状颗粒细胞苔藓纤维的兴奋性输入，两条通路均表现出LTP。虽然联合连合LTP的诱导需要在突触后细胞N-甲基-D-天冬氨酸（NMDA）受体激活，膜去极化，和钙的上升，苔藓纤维LTP不。成对脉冲易化，这是一个增加的递质释放的指数，在联合连合LTP期间不变，但在苔藓纤维LTP期间减少。因此，苔藓纤维LTP的诱发和持续变化可能是突触前的，而联合连合LTP则不是。
In invertebrate nervous systems, some long-lasting increases in synaptic efficacy rsult from changes in the presynaptic cell. In the vertebrate nervous system, the best understood long-lasting change in synaptic strength is long-term potentiation (LTP) in the CA1 region of the hippocampus. Here the process is initiated postsynaptically, but the site of the persistent change is unresolved. Single CA3 hippocampal pyramidal cells receive excitatory inputs from associational-commissural fibers and from the mossy fibers of dentate granule cells and both pathways exhibit LTP. Although the induction of associational-commissural LTP requires in the postsynaptic cell N-methyl-D-aspartate (NMDA) receptor activation, membrane depolarization, and a rise in calcium, mossy fiber LTP does not. Paired-pulse facilitation, which is an index of increased transmitter release, is unaltered during associational-commissural LTP but is reduced during mossy fiber LTP. Thus, but the induction and the persistent change may be presynaptic in mossy fiber LTP but not in associational-commissural LTP.