Comparative Analysis of the Roles of Non-muscle Myosin-IIs in Cytokinesis in Budding Yeast, Fission Yeast, and Mammalian Cells.
Comparative Analysis of the Roles of Non-muscle Myosin-IIs in Cytokinesis in Budding Yeast, Fission Yeast, and Mammalian Cells.
复制标题
非肌肉肌球蛋白-II在萌芽酵母，裂变酵母和哺乳动物细胞中的作用的比较分析。
DOI：
10.3389/fcell.2020.593400
复制
发表时间：
2020
影响因子：
5.5
通讯作者：
Bi E
中科院分区：
文献类型：
--
作者：
Wang K;Okada H;Bi E
收缩环在真菌和动物细胞的胞质分裂中起着关键作用，几十年来一直吸引着生物学家。然而，非肌肉肌球蛋白-II和肌动蛋白丝如何组装成环状结构以驱动胞质分裂的基本问题仍然知之甚少。更神秘的是，为什么以及如何芽殖酵母酿酒酵母、裂殖酵母粟酒裂殖酵母和人类分别用一种、两种和三种肌球蛋白II同种型构建环状结构。在这里，我们提供了一个比较分析的作用，非肌肉肌球蛋白II在胞质分裂在这三个模型系统中，定义的共同和独特的功能，并突出这个家庭的蛋白质的主要问题的目标。
The contractile ring, which plays critical roles in cytokinesis in fungal and animal cells, has fascinated biologists for decades. However, the basic question of how the non-muscle myosin-II and actin filaments are assembled into a ring structure to drive cytokinesis remains poorly understood. It is even more mysterious why and how the budding yeast Saccharomyces cerevisiae, the fission yeast Schizosaccharomyces pombe, and humans construct the ring structure with one, two, and three myosin-II isoforms, respectively. Here, we provide a comparative analysis of the roles of the non-muscle myosin-IIs in cytokinesis in these three model systems, with the goal of defining the common and unique features and highlighting the major questions regarding this family of proteins.