DEPENDENCE OF CORTICAL PLASTICITY ON CORRELATED ACTIVITY OF SINGLE NEURONS AND ON BEHAVIORAL CONTEXT
DEPENDENCE OF CORTICAL PLASTICITY ON CORRELATED ACTIVITY OF SINGLE NEURONS AND ON BEHAVIORAL CONTEXT
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DOI：
10.1126/science.1529342
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发表时间：
1992-09-04
期刊：
影响因子：
56.9
通讯作者：
ABELES, M
中科院分区：
文献类型：
--
作者：
AHISSAR, E;VAADIA, E;ABELES, M
由于在清醒动物的细胞内记录存在困难，因此无法分析行为哺乳动物学习的细胞机制。因此，在本研究中的神经元可塑性的行为猴子，一个单一的神经元对另一个神经元（“功能连接”）的净效应进行了评估，通过互相关的时间发射的两个神经元。当两个神经元被诱导在短时间内同时放电时，它们之间的功能连接被加强，当同时放电被阻止时，连接被抑制。这些修改强烈依赖于诱导它们的刺激的行为背景。结果表明，神经元之间的时间偶然性的变化往往是必要的，但不是足够的，在成年猴的皮质可塑性：行为相关性是必需的。
It has not been possible to analyze the cellular mechanisms underlying learning in behaving mammals because of the difficulties in recording intracellularly from awake animals. Therefore, in the present study of neuronal plasticity in behaving monkeys, the net effect of a single neuron on another neuron (the "functional connection") was evaluated by cross-correlating the times of firing of the two neurons. When two neurons were induced to fire together within a short time window, the functional connection between them was potentiated, and when simultaneous firing was prevented, the connection was depressed. These modifications were strongly dependent on the behavioral context of the stimuli that induced them. The results indicate that changes in the temporal contingency between neurons are often necessary, but not sufficient, for cortical plasticity in the adult monkey: behavioral relevance is required.