Feline Hypertrophic Cardiomyopathy: A Spontaneous Large Animal Model of Human HCM.
Feline Hypertrophic Cardiomyopathy: A Spontaneous Large Animal Model of Human HCM.
复制标题
猫型心肌病：人类HCM的自发大型动物模型。
DOI：
10.14740/cr578w
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发表时间：
2017-08
影响因子：
1.9
通讯作者：
Maron MS
中科院分区：
文献类型：
--
作者：
Freeman LM;Rush JE;Stern JA;Huggins GS;Maron MS
肥厚性心肌病（HCM）是宠物猫的常见病，影响10-15%的宠物猫。猫HCM与人类HCM的相似性、疾病的快速进展以及明确且易于确定的终点使其成为一种与人类HCM具有基因型和表型相似性的优秀天然模型。缅因猫和布娃娃猫是特别有价值的HCM模型，因为它们有肌球蛋白结合蛋白c突变，与所有猫科动物相比，它们的发病率更高。猫克服了啮齿动物HCM模型的许多局限性，并且可以提供从体外和诱导小动物模型到人类临床试验的增强信息翻译。医生和兽医以协作和跨学科的方式共同努力，可以加速发现更有效的治疗这种疾病和其他影响人类和兽医患者的心血管疾病的方法。
Hypertrophic cardiomyopathy (HCM) is a common disease in pet cats, affecting 10-15% of the pet cat population. The similarity to human HCM, the rapid progression of disease, and the defined and readily determined endpoints of feline HCM make it an excellent natural model that is genotypically and phenotypically similar to human HCM. The Maine Coon and Ragdoll cats are particularly valuable models of HCM because of myosin binding protein-C mutations and even higher disease incidence compared to the overall feline population. The cat overcomes many of the limitations of rodent HCM models, and can provide enhanced translation of information from in vitro and induced small animal models to human clinical trials. Physicians and veterinarians working together in a collaborative and interdisciplinary approach can accelerate the discovery of more effective treatments for this and other cardiovascular diseases affecting human and veterinary patients.