Metabolism and Clinical Implications of Branched Chain Amino and Keto Acids
Metabolism and Clinical Implications of Branched Chain Amino and Keto Acids
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支链氨基酸和酮酸的代谢和临床意义
DOI：
10.1042/bst0100143
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发表时间：
1982
影响因子：
3.9
通讯作者：
M. Scrutton
中科院分区：
文献类型：
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作者：
M. Scrutton
多年来，氨基酸代谢是一个被忽视的领域。代谢途径的知识往往是不完整的，而对氨基酸催化剂调节的潜在机制的理解是最小的，如果它存在的话。Cahill、Felig和其他人的开创性研究表明了碳水化合物、脂质和氨基酸代谢之间的重要相互关系，因此为更详细地研究哺乳动物组织中氨基酸代谢的模式以及负责观察到的特异性和相互作用的机制提供了动力。最引人注目的观察之一是证明了在处理支链氨基酸时的组织特异性，支链氨基酸是球状蛋白质的主要成分。因此，在过去的几年里，人们一直致力于研究支链氨基酸代谢的调节以及与其他代谢燃料（如葡萄糖和酮体）的相互作用。这样的活动不可避免地产生了会议，1980年11月举行的一次为期两天的会议的记录在本卷中有报道。所涵盖的领域是广泛的（如标题所示），从降解途径的纯化酶的特性到支链氨基酸在脓毒症和创伤治疗中的应用。介于这两个极端之间的利益领域也得到了很好的代表。我只能得出这样的结论，那次会议一定是一次繁忙的会议，我很想知道与会者是如何度过的！已出版的会议记录包括由照相制版准备的长度大致相同的文章。因此，读者只能猜测哪些文章来自受邀演讲，哪些来自临床研讨会，哪些来自海报展示。内容也不是很有帮助，因为绝大多数作者都集中在数据的介绍，而不是对调查领域的评价。结果是一本书，提供了1980年支链氨基酸代谢研究状况的文学“照片”。鉴于目前的研究活动在这一领域的步伐，这本书将有一个相当短的寿命作为当前的信息来源，此后将在很大程度上是历史的兴趣，虽然广泛的主题涵盖可能使它有用的基础科学家和临床医生之间的交叉受精与共同利益的支链氨基酸和酮酸。M.斯克鲁顿
For many years amino acid metabolism was a neglected area. Knowledge of metabolic pathways was often imcomplete, while understanding of the mechanisms underlying the regulation of amino acid catabolism was minimal if it existed at all. The pioneering studies of Cahill, Felig and others indicated the crucial interrelationships between the metabolism of carbohydrates, lipids and amino acids, and provided therefore impetus for a more detailed examination of the pattern of amino acid catabolism in the tissues of mammals and of the mechanisms responsible for the observed specificities and interactions. One of the most striking observations has been the demonstration of tissue specificity in the handling of the branched-chain amino acids, which are major constituents of globular proteins. Thus over the past few years much effort has been devoted to studies on branched-chain-amino-acid metabolism in respect both to regulation and to interaction with other metabolic fuels, eg glucose and ketone bodies. Such activity inevitably breeds conferences, and the proceedings of one such meeting held over 2 days in November 1980, are reported in this volume. The field covered is a wide one (as indicated by the title), ranging from the properties of purified enzymes of the degradative pathway to the use of branched-chain amino acids in the treatment of sepsis and trauma. Areas of interest intermediate between these two extremes are also well represented. I can only conclude that the meeting must have been a hectic affair and am tempted to wonder how well the participants survived it! The published proceedings consist of articles of approximately uniform length prepared by photo-offset from cameraready copy. Hence the reader can only guess which articles derive from the invited talks, which from the clinical workshops and which from the poster presentations. The content is also not very helpful, since the vast majority of the authors have focussed on presentation of data rather than on evaluation of an area of investigation. The result is a book which provides a literary ‘photograph’of the state of studies in branched-chain-aminoacid metabolism in 1980. Given the current pace of research activity in this area the book will have a rather short lifespan as a current information source and thereafter will be largely of historical interest, although the broad spectrum of topics covered may make it useful for cross-fertilisation between basic scientists and clinicians with a common interest in the branched-chain amino and keto acids. M. SCRUTTON